Publications by authors named "Sebastien Dam"
Quantifying Apathy in Late-Life Depression: Unraveling Neurobehavioral Links Through Daily Activity Patterns and Brain Connectivity Analysis.
Biol Psychiatry Cogn Neurosci Neuroimaging
July 2024
Article Synopsis
- A study explored the links between motor activity patterns, apathy, and brain connectivity in older adults with late-life depression to improve predictions for conditions like dementia.
- Using actimetry, resting-state fMRI, and diffusion MRI, researchers assessed 38 participants and identified two key activity patterns related to apathy: mean diurnal activity and early chronotype.
- The study found that both patterns were associated with notable brain network connectivity but did not establish a significant connection with microstructural brain metrics.
The treatment of depressive episodes is well established, with clearly demonstrated effectiveness of antidepressants and psychotherapies. However, more than one-third of depressed patients do not respond to treatment. Identifying the brain structural basis of treatment-resistant depression could prevent useless pharmacological prescriptions, adverse events, and lost therapeutic opportunities.
View Article and Find Full Text PDFBackground: Apathy is associated with reduced antidepressant response and dementia in late-life depression (LLD). However, the functional cerebral basis of apathy is understudied in LLD. We investigated the functional connectivity of 5 resting-state networks (RSN) hypothesized to underlie apathy in LLD.
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