Publications by authors named "Sebastien Christophe"
Article Synopsis
- Low molecular weight heparins (LMWH) are often used in ICU for preventing blood clots and treating blood clot disorders during renal replacement therapy (RRT).
- A rare side effect of LMWH can be skin necrosis at injection sites, which may indicate an immunoallergic reaction known as heparin-induced thrombocytopenia (HIT).
- In a reported case, a patient developed skin necrosis after RRT without showing low platelet counts, and various tests were suggested to help diagnose the condition, given the low likelihood indicated by the 4T's scoring system.
Introduction: Adequate volume expansion (VE) in patients with evidence of hypoperfusion should be aimed not only at achieving an increase in stroke volume (SV) and cardiac index (CI) but also at improved tissue perfusion and oxygenation. Our aim in this study was to assess the dynamic changes in muscle tissue oxygen saturation (StO₂) during hypovolaemia and in response to VE.
Methods: We conducted a prospective study of 42 fluid challenges in patients undergoing major abdominal surgery with evidence of hypovolaemia, defined as pulse pressure variation (PPV) >13% and SV variation (SVV) >12%.