Publications by authors named "Sebastiano Biondo"

Background/objectives: Colon cancer presents as an obstruction in almost 30% of patients. Self-expandable metallic stents emerged as an alternative to emergency surgery, despite early controversies around their use. Improved techniques led to stent incorporation in clinical guidelines.

View Article and Find Full Text PDF
Article Synopsis
  • Organ preservation through the Watch and Wait (WW) approach in rectal cancer patients shows promise but poses a risk of local regrowth (LR), leading to higher rates of distant metastases (DM) compared to traditional surgery (TME).
  • A study comparing 508 LR patients managed by WW and 893 near-complete pathologic response (nPCR) patients after TME found a significantly higher DM rate in the LR group (22.8% vs. 10.2%).
  • The research concluded that patients with LR have poorer 3-year DM-free survival (75% vs. 87%) and highlight that leaving a primary undetectable tumor can result in worse overall outcomes.
View Article and Find Full Text PDF

Importance: In patients operated on for low rectal cancer, 2-stage Turnbull-Cutait pull-through hand-sewn coloanal anastomosis provides benefits in terms of postoperative morbidity compared with standard hand-sewn coloanal anastomosis associated with diverting ileostomy and further ileostomy reversal.

Objective: To compare long-term results of these 2 techniques after ultralow rectal resection for rectal cancer.

Design, Setting, And Participants: In this randomized multicenter clinical trial, neither patients nor surgeons were blinded for technique.

View Article and Find Full Text PDF

There is no international consensus on the definition of the type of oncological resection that corresponds to each of the colectomies existing in the current literature. The objective is to define for each colectomy described in the literature: embryological dissection plane, vascular pedicles in which to perform central ligation, the extent of the colectomy, and the need for resection of the greater momentum. A consensus of experts is carried out through the Delphi methodology through two rounds from the Coloproctology Section of the Spanish Association of Surgeons.

View Article and Find Full Text PDF

Background: The Catalan Cancer Plan (CCP) undertakes periodic audits of cancer treatment outcomes, including organ/space surgical site infections (O/S-SSI) rates, while the Catalan Healthcare-associated Infections Surveillance Programme (VINCat) carries out standardized prospective surveillance of surgical site infections (SSI) in colorectal surgery. This cohort study aimed to assess the concordance between these two monitoring systems for O/S-SSI following primary rectal cancer surgery.

Methods: The study compared O/S-SSI incidence data from CCP clinical audits versus the VINCat Programme in patients undergoing surgery for primary rectal cancer, in 2011-12 and 2015-16, in publicly funded centres in Spain.

View Article and Find Full Text PDF

Purpose: Chemotherapy is established as primary treatment in patients with stage IV colorectal cancer and unresectable metastases. Data from nonrandomized clinical trials have fueled persistent uncertainty if primary tumor resection (PTR) before chemotherapy prolongs survival. We investigated the prognostic value of PTR in patients with newly diagnosed stage IV colon cancer who were not amenable to curative treatment.

View Article and Find Full Text PDF
Article Synopsis
  • Various neoadjuvant treatments for advanced colon cancer are becoming available, and effective preoperative staging is essential for choosing the right approach.
  • A study involving 50 centers and 1,950 patients focused on the diagnostic accuracy of CT scans for T4 colon tumors, revealing significant limitations in terms of sensitivity and specificity for staging.
  • The findings indicated that while CT had high accuracy for detecting peritoneal metastases, its overall performance for T4 staging and lymph node classification was inadequate, highlighting the need for improved diagnostic methods.
View Article and Find Full Text PDF

We aimed to identify and validate a set of miRNAs that could serve as a prognostic signature useful to determine the recurrence risk for patients with COAD. Small RNAs from tumors of 100 stage II, untreated, MSS colon cancer patients were sequenced for the discovery step. For this purpose, we built an miRNA score using an elastic net Cox regression model based on the disease-free survival status.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the effectiveness of self-expandable metal stents compared to emergency resection for treating right-sided obstructive colon cancer, highlighting growing interest in stents as a surgical bridge.
  • - An analysis of 6,343 patients showed a high success rate for stent placement (92%) and lower emergency resection mortality rates (5%), with similar rates of complications between both methods.
  • - The authors conclude that using stents is a safe and effective alternative to emergency resection, potentially allowing for more minimally invasive surgical options, though they note a lack of randomized controlled trials in their review.
View Article and Find Full Text PDF

Background: Use of antibiotics in selected cases of acute uncomplicated diverticulitis (AUD) has recently been questioned.

Objective: The aim of this study is to examine the safety and efficacy of treatment regimens without antibiotics compared with that of traditional treatments with antibiotics in selected patients with AUD.

Data Sources: PubMed, Medline, Embase, Web of Science, and the Cochrane Library.

View Article and Find Full Text PDF

Introduction: Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) is a safe and effective technique with good short- and mid-term weight control and associated medical problems remission for patients with a body mass index (BMI) > 45 kg/m. The aim of this study was to analyze patient-reported symptoms, specifically symptomatic gastroesophageal reflux disease symptoms (GERD), depositional habit, and quality of life (QOL) following SADI-S, using telemedicine and validated tests.

Methods: A prospective unicentric cross-sectional study was conducted including all patients submitted to SADI-S in the University Hospital of Bellvitge from May 2014 to September 2019.

View Article and Find Full Text PDF

Background: Colorectal cancer management may require an ostomy formation; however, a stoma may negatively impact health-related quality of life (HRQoL). This study aimed to compare generic and stoma-specific HRQoL in patients with a permanent colostomy after rectal cancer across different countries.

Method: A cross-sectional cohorts of patients with a colostomy after rectal cancer in Denmark, Sweden, Spain, the Netherlands, China, Portugal, Australia, Lithuania, Egypt, and Israel were invited to complete questionnaires regarding demographic and socioeconomic factors along with the Colostomy Impact (CI) score, European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30) and five anchor questions assessing colostomy impact on HRQoL.

View Article and Find Full Text PDF
Article Synopsis
  • The study looked at why surgeons decide to do a protective ileostomy after a certain type of surgery for rectal cancer.
  • Most surgeons (76%) agreed on doing the ileostomy, and many (88%) considered certain risk factors before deciding.
  • The study found that emotions and personal experiences played a big role in the decisions surgeons made, but there aren't clear guidelines on when to perform this procedure yet.
View Article and Find Full Text PDF
Article Synopsis
  • Lynch syndrome (LS) is a genetic condition that increases the risk of colorectal cancer and other cancers, but many people with it don't know they have it.
  • A study was done on people under 70 with colorectal cancer to see how well they could be screened for LS, which involved checking their tissue samples for specific protein changes.
  • Out of 381 people in the study, 10 were diagnosed with LS and it helped find 26 more family members at risk through follow-up testing.
View Article and Find Full Text PDF

Colonomics is a multi-omics dataset that includes 250 samples: 50 samples from healthy colon mucosa donors and 100 paired samples from colon cancer patients (tumor/adjacent). From these samples, Colonomics project includes data from genotyping, DNA methylation, gene expression, whole exome sequencing and micro-RNAs (miRNAs) expression. It also includes data from copy number variation (CNV) from tumoral samples.

View Article and Find Full Text PDF

Background: Surgical failure-to-rescue (FTR, death rate following complications) is a reliable cross-sectional quality of care marker, but has not been evaluated dynamically. We aimed to study changes in FTR following emergency surgery during the COVID-19 pandemic.

Material And Methods: Matched cohort study including all COVID-19-non-infected adult patients undergoing emergency general surgery in 25 Spanish hospitals during COVID-19 pandemic peak (March-April 2020), non-peak (May-June 2020), and 2019 control periods.

View Article and Find Full Text PDF

Background: Benchmark comparisons in surgery allow identification of gaps in the quality of care provided. The aim of this study was to determine quality thresholds for high (HAR) and low (LAR) anterior resections in colorectal cancer surgery by applying the concept of benchmarking.

Methods: This 5-year multinational retrospective study included patients who underwent anterior resection for cancer in 19 high-volume centres on five continents.

View Article and Find Full Text PDF

Purpose: Stoma-related problems are known to be important to patients and potentially affect everyday life. The prevalence of stoma-related problems in rectal cancer survivors remains undetermined. This study aimed to examine aspects of life with a long-term stoma, stoma management, and stoma-related problems and explore the impact of stoma-related problems on daily life.

View Article and Find Full Text PDF