Publications by authors named "Sebastian Wyschkon"
CVIR Endovasc
November 2021
Article Synopsis
- A simulator was designed for novices to practice embolization with n-Butyl cyanoacrylate (n-BCA) and was evaluated using surveys and video analysis.
- Participants, consisting of 12 novices and 5 experts, completed questionnaires pre- and post-simulation, performed embolizations, and assessed the simulator's effectiveness.
- Results showed that experts found the simulator very useful, novices significantly improved their confidence, and the time taken for novices to perform procedures was longer compared to experts, indicating it is an effective training tool for beginners.
ESC Heart Fail
October 2020
Article Synopsis
- Heart failure is common in acute ischemic stroke patients, and cardiovascular MRI can help identify cardiac function issues.
- In a study with 229 stroke patients, systolic dysfunction was found in 25% and diastolic dysfunction in 59% of cases, indicating a significant prevalence of heart dysfunction.
- Both real-time and segmented MRI imaging methods showed similar effectiveness in assessing heart function, highlighting that CRT imaging is a viable option for diagnosis.
Article Synopsis
- The study aimed to compare the effectiveness of diastolic function parameters obtained from long-axis (LAX) vs. short-axis (SAX) cardiac MRI in diagnosing diastolic dysfunction.
- A total of 40 participants, including healthy individuals and patients with different severities of diastolic dysfunction, were analyzed using volume-time curves derived from both imaging methods.
- Results indicated that LAX-derived parameters, especially the E/A ratio, had high diagnostic accuracy for identifying diastolic dysfunction and required less time for analysis compared to SAX.
Article Synopsis
- This study evaluated 3T MRI techniques to distinguish between infectious and malignant solid lung lesions in immunocompromised patients and compared them to control patients with different lung conditions.
- Results showed that infectious lesions had significantly higher T2-NICQ values compared to malignant ones, and a combination of T2-NICQ and T1-Q improved diagnostic accuracy.
- The findings suggest that T2-NICQ is particularly useful for differentiating acute infections from malignancies in lungs, with high specificity when used alone or in combination with T1-Q.
Article Synopsis
- The study evaluates a short MRI protocol for detecting lung nodules in immunocompromised patients with suspected fungal infections.
- MRI was performed on 13 patients, showing high sensitivity (93.2%) for detecting nodules detected earlier by CT scans, which increased to 97.9% for larger nodules.
- The findings suggest that MRI is a feasible and reliable alternative for monitoring these patients with an average examination time of only 12 minutes.
J Vasc Access
December 2016
Article Synopsis
- The study assessed how body mass index (BMI) affects the positioning of implanted port devices using chest x-rays and fluoroscopy.
- Data from 80 patients were analyzed, focusing on three measurement methods to evaluate port positions, accounting for variations between genders and weight categories.
- The findings indicated that overweight women experienced more significant changes in port positioning compared to other groups, with recognized reproducibility in measurements, especially in the EX/IV ratio and PCP assessments.
Article Synopsis
- The study aimed to explore how the cerebral renin-angiotensin system is regulated after head trauma and the effects of blocking angiotensin II receptor type 1 (AT1R) on brain damage and recovery.
- Researchers used male mice to measure components of this system at various time points after a controlled head trauma, employing a drug called candesartan to inhibit AT1R and analyze its impact on brain injury and inflammation.
- Results revealed that AT1R inhibition soon after injury reduced secondary brain damage and inflammation, with prolonged treatment leading to better long-term neurological outcomes, although it did not significantly decrease brain swelling.
Article Synopsis
- Quantitative measurements of gene expression need to account for factors like tissue sample size and RNA quantity, which can be normalized using stable control genes.
- A study tested male C57Bl/6 mice after inducing brain trauma and measured expression of multiple control and target genes over various time points post-injury.
- B2M and cyclophilin A were found to be stable control genes up to 12 hours post-trauma, making them suitable for normalizing gene expression data, while other genes showed variable responses depending on timing and tissue status.
