Determinants of Overall and Readmission-Free Survival in Patients with Metastatic Epidural Spinal Cord Compression.

Background: The aim of this study was to assess the surgical outcomes and survival of patients surgically treated for metastatic epidural spinal cord compression (MESCC), with a specific focus on identifying factors that influence overall survival and readmission-free survival.

Methods: All patients who underwent surgery for spine metastases at our department in the period 2018-2022 were included in the study.

Results: A total of 175 patients (n = 71 females, median age 67.

DOTA-Based Plectin-1 Targeted Contrast Agent Enables Detection of Pancreatic Cancer in Human Tissue.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal malignancy with extremely poor patient survival rates. A key reason for the poor prognosis is the lack of effective diagnostic tools to detect the disease at curable, premetastatic stages. Tumor surgical resection is PDAC's first-line treatment, however distinguishing between cancerous and healthy tissue with current imaging tools remains a challenge.

Does size matter? - Comparing pyranoses with septanoses as ligands of the bacterial lectin FimH.

The pharmacological modulation of disease-relevant carbohydrate-protein interactions represents an underexplored area of medicinal chemistry. One particular challenge in the design of glycomimetic compounds is the inherent instability of the glycosidic bond toward enzymatic cleavage. This problem has traditionally been approached by employing S-, N-, or C-glycosides with reduced susceptibility toward glycosidases.

An alternative soft tissue analysis following mandibular setback by sagittal split ramus osteotomy.

Objective: The objective of this study was to determine alternative ratios of soft-to-hard tissue movement after mandibular setback, taking skeletal relapse and differing patterns of facial divergence into account.

Study Design: Thirty patients were analyzed cephalometrically over a mean follow-up period of 14 months.

Results: The relationship between skeletal and soft tissue movements in the mentolabial folds and at the pogonion was 1:1.