Publications by authors named "Sebastian Wangler"
Article Synopsis
- A greater tuberosity fractures make up about 20% of proximal humeral fractures and their treatment relies on accurate measurement of fracture displacement.
- The study evaluated the reliability of different radiographic measurement methods and their ability to predict displacement seen in CT scans using 49 cases of these fractures.
- Results demonstrated excellent reliability for some methods and confirmed that CT scans could be effectively used to measure various displacement types, supporting the use of radiographic indicators for treatment decisions.
Development of the humeral head offset index for control of humeral torsion.
BMC Musculoskelet Disord
September 2024
Article Synopsis
- The study aimed to create and validate a method for assessing humeral torsion using a single x-ray image, simplifying intraoperative procedures.
- The Humeral Head Offset Index (HHOI) is calculated by comparing the medial and lateral humeral head offsets, and was tested on models and patient CT images to determine its reliability.
- Results showed a strong correlation between the HHOI and humeral torsion, indicating the method's effectiveness for clinical application.
Article Synopsis
- Cat bite injuries are often underestimated by both patients and healthcare providers, leading to potentially serious complications due to bacteria in the cat's saliva.
- A retrospective study of 102 adult patients was conducted to analyze the impact of timing in treatment (first presentation, antibiotic start, and surgery) on microbiological results and outcomes.
- The findings indicated that timing did not significantly affect microbiological outcomes, and no notable differences were found in complication rates, hospital stays, or treatment costs based on bacterial growth.
Article Synopsis
- Digitally reconstructed radiographs (DRRs) are 2D images derived from 3D CT scans, aiding in pre-surgical planning, while C-arm fluoroscopy is commonly used during surgery but has a technical issue known as pincushion distortion.
- The study involved 3D-printed models and analyzed the correlation between DRRs, fluoroscopic images, and conventional X-rays using rotations from 0 to 90 degrees to evaluate accuracy.
- Results showed high correlation between DRRs and both X-ray (R 0.99) and C-arm images (R 0.95), with the highest structural similarity index (SSIM) between DRR and C-arm images, confirming DRRs as a reliable research tool in orthopedic imaging
Article Synopsis
- The study examines how pro-inflammatory cytokines affect human annulus fibrosus cells (hAFCs) and their ability to sensitize dorsal root ganglion (DRG) cells.
- Celecoxib (cxb) was tested to see if it could inhibit this sensitization, with results showing that it effectively reduced PGE-2 production in hAFCs and lowered DRG cell sensitivity to bradykinin.
- Overall, the findings suggest that cxb may be beneficial in minimizing nerve sensitization related to inflamed hAFCs.
Article Synopsis
- Cell transplantation using mesenchymal stromal cells (MSCs) shows potential for repairing intervertebral discs (IVDs) but faces issues such as needle-related damage and low nutrient availability.
- A study using female rats tested MSC transplantation into vertebrae next to healthy or damaged IVDs, measuring disc height and tissue integrity over time. Results indicated that MSCs led to better maintenance of disc height and overall integrity compared to saline treatments.
- The findings suggest that transplanting MSCs vertebrally improves IVD repair by leveraging natural cell migration, making it a potentially effective alternative to direct disc injections for addressing disc degeneration.
Article Synopsis
- The study analyzed outcomes of rotating hinge knee (RHK) implants in 63 cases (19 primary, 44 revisions) over an average follow-up of 34 months.
- Results showed that while primary cases had better scores in the Hospital of Special Surgery (HSS) and Oxford Knee Score (OKS), overall functional measurements were comparable between primary and revision cases.
- The RHK arthroplasty demonstrated good clinical outcomes and a low revision rate (6.3%) with a high implant survival rate (96.8%), indicating its suitability for complex cases.
Article Synopsis
- The study aimed to provide long-term outcomes for revised total knee arthroplasties (rTKA) and compare one-stage versus two-stage revisions, as well as septic versus aseptic cases.
- A total of 44 patients were followed up for a minimum of five years, revealing that the main reasons for rTKA were aseptic loosening and periprosthetic joint infection, with an 89% implant survivorship observed at final follow-up.
- Functional outcome scores indicated medium-range results, while patient satisfaction was relatively high, showing no significant differences between the subgroups analyzed.
Article Synopsis
- Chronic low back pain (LBP) is difficult to treat, and spinal fusion is currently the most common solution when conservative treatments fail, despite its invasive nature.
- Research is increasingly focusing on cell-based therapies, particularly the use of mesenchymal stromal cells (MSCs), to heal damaged intervertebral discs (IVDs) by mimicking the body’s natural healing processes.
- This literature review summarizes recent advancements in MSC applications for IVD regeneration, discusses their effective uses and limitations, and explores future strategies to enhance their repair capabilities.
Article Synopsis
- The pilot study tested a hydrogel made of hyaluronic acid (HA) and platelet-rich plasma (PRP) to see how it affects human mesenchymal stem cells (hMSCs) in repairing intervertebral discs (IVDs).
- It involved using hyaluronic acid mixed with batroxobin and PRP to create a hydrogel that contained hMSCs and then placing this mixture inside bovine IVDs to observe its performance.
- Results showed that the hydrogel with hMSCs maintained disc tissue viability, preserved its structure, and promoted hMSC differentiation into a specific cell type associated with the IVD, indicating that this hydrogel may be an effective treatment for disc regeneration.
Article Synopsis
- This study investigates the degeneration of paraspinal lumbar muscles using T2-weighted MRI, focusing on fatty infiltration as a key indicator of degeneration.
- The research utilizes a new software application to analyze different muscle groups (mono-, multi-, and pluri-segmental) in a sample of 120 segments, revealing that mono-segmental muscles had significantly higher fatty infiltration levels compared to the others.
- Findings indicate that mono-segmental muscles, particularly at the L4/5 and L5/S1 levels, are more affected by degeneration, with age and disc grade serving as independent risk factors for fatty muscle degeneration.
Article Synopsis
- Mesenchymal stromal cells (MSCs) are being explored for regenerative medicine due to their ability to differentiate into various cell types and release bioactive factors that promote healing and reduce cell death.
- A study analyzed how MSCs respond to different intervertebral disc (IVD) environments (healthy, traumatic, and degenerative) by examining the proteins they secrete, revealing significant changes in their secretome based on the condition they were exposed to.
- The research indicates that the secretome is tailored to meet the specific needs of the IVD, suggesting that customizing these secretomes could enhance therapeutic strategies for IVD-related injuries and diseases.
Article Synopsis
- The study explored the effect of human mesenchymal stem cell (MSC) homing on the regeneration of intervertebral discs (IVDs), which are crucial for spinal health.
- MSCs were introduced to both bovine and human IVDs, showing that their presence increased the Tie2-positive progenitor cells, stimulated cell proliferation, and reduced cell death.
- The results suggest that MSC homing might be a promising method for improving IVD cell survival and could help in preventing degeneration in at-risk discs.
Article Synopsis
- Leakage is a common issue during spine cement augmentation, with the viscosity of PMMA cement influencing the risk of leakage.
- A study tested three different injection techniques: all-in-one, two-step, and sequential, to determine their effect on leakage rates in a vertebroplasty model.
- Results showed that the sequential injection technique significantly reduced leakage (2/20 cases) compared to the other methods, indicating it as a more effective approach for minimizing cement leakage during procedures.