Publications by authors named "Sebastian W Draxler"
Article Synopsis
- Fragment-based drug discovery (FBDD) helps researchers explore a large variety of potential drug compounds by Screening small fragments and determining how they interact with proteins using techniques like X-ray crystallography.
- In a study, researchers screened 15 very small fragments computationally and found three key interaction sites on the FKBP51 FK1 domain, achieving a hit rate of 40% with six successful X-ray co-structures.
- The study suggests a hybrid approach that combines computational methods, X-ray screening, and N HSQC NMR to quickly identify promising drug candidates and their binding interactions.
