Publications by authors named "Sebastian Shine Kwapong"
Article Synopsis
- The study investigates malaria patterns and IgG antibody levels in suspected patients in Ghana, highlighting the disease's prevalence as a major health issue in the country.
- A total of 823 participants aged 1 to 85 were analyzed for antibody responses against various malaria proteins using ELISA, with significant findings indicating higher antibody levels with increasing age.
- Results show notable variations in antibody responses by region and age, particularly for proteins MSP3, GLURP-RO, and gSG6-P1, underscoring the need for targeted malaria control strategies.
Background: The human host elicits specific immune responses after exposure to various life stages of the malaria parasite as well as components of mosquito saliva injected into the host during a mosquito bite. This study describes differences in IgG responses against antigens derived from the sporozoite (PfCSP), asexual stage parasite (PfEBA175) and the gametocyte (Pfs230), in addition to an Anopheles gambiae salivary gland antigen (gSG6-P1), in two communities in Ghana with similar blood stage malaria parasite prevalence.
Methods: This study used archived plasma samples collected from an earlier cross-sectional study that enrolled volunteers aged from 6 months to 70 years from Simiw, peri-urban community (N = 347) and Obom, rural community (N = 291).