Publications by authors named "Sebastian Romann"
Mitochondrial respiratory pathways in immature rat heart tissue using different cardioplegic solutions.
Gen Thorac Cardiovasc Surg
November 2024
Article Synopsis
- Minor defects in the mitochondrial ATP-generating system can harm heart function in immature hearts, so this study explored various cardioplegic solutions.
- The experiment involved 41 male rats and compared the effects of three solutions (St. Thomas, Custodiol HTK, and Del Nido) during 1-hour and 3-hour ischemic periods.
- Results showed that the Del Nido solution offered the best mitochondrial respiration and ATP production compared to the other solutions, particularly after extended ischemia.
Purpose Of The Review: Elevated troponin levels are well established e.g., for the diagnosis of suspected acute coronary syndrome in symptomatic patients.
View Article and Find Full Text PDFThe emerging field of cardio-oncology addresses the critical need for specialized cardiovascular care in cancer patients, given the overlapping risk factors and potential cardiovascular complications of oncological therapies. In collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO), and the European Society of Cardiology (ESC), the first cardio-oncology guideline was developed and published in 2022. This guideline comprises 272 recommendations covering risk stratification before therapy initiation, monitoring during oncological treatment, and the diagnosis and treatment of therapy-associated cardiovascular side effects.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the cardiovascular risks associated with CAR T cell therapies in cancer patients, focusing on potential heart damage.
- It examines 137 patients from 2018-2022, assessing cardiac biomarkers and functions to predict severe cardiac events and overall mortality.
- Findings note that changes in a specific biomarker (hs-cTnT) shortly after treatment can predict all-cause mortality, while traditional risk factors and baseline measures did not effectively indicate cardiac issues.
Aims: Oncological patients suspected at risk for cardiotoxicity are recommended to undergo intensified cardiological surveillance. We investigated the value of cardiac biomarkers and patient-related risk factors [age, cardiovascular risk factors (CVRFs), and cardiac function] for the prediction of all-cause mortality (ACM) and the development of cardiotoxicity.
Methods And Results: Between January 2016 and December 2020, patients with oncological diseases admitted to the Cardio-Oncology Unit at the Heidelberg University Hospital were included.
Aims: Cardio-oncology is a growing interdisciplinary field which aims to improve cardiological care for cancer patients in order to reduce morbidity and mortality. The impact of cardiac biomarkers, echocardiographic parameters, and cardiological assessment regarding risk stratification is still unclear. We aimed to identify potential parameters that allow an early risk stratification of cancer patients.
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