Publications by authors named "Sebastian R Vanin"
Article Synopsis
- Prenatal exposure to specific components of cannabis, like THC and CBD, has been linked to increased risks of neuropsychiatric disorders, affecting both males and females differently.
- In a rat model study, offspring exposed to these cannabinoids showed low birth weight and distinct behavioral changes related to anxiety and social cognition during adolescence.
- Analysis of brain regions involved in cognitive development revealed that prenatal cannabinoid exposure disrupts the endocannabinoid system, leading to potential long-term neurodevelopmental issues.
Reports in North America suggest that up to 20% of young women (18-24 years) use cannabis during pregnancy. This is concerning given clinical studies indicate that maternal cannabis use is associated with fetal growth restriction and dysglycemia in the offspring. Preclinical studies demonstrated that prenatal exposure to Δ9-tetrahydrocannabinol, the main psychoactive component of cannabis, in rat dams led to female-specific deficits in β-cell mass and glucose intolerance/insulin resistance.
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