Sedation and Analgesia for Toxic Epidermal Necrolysis in the Intensive Care Unit: Few Certainties, Many Questions Ahead.

Toxic epidermal necrolysis (TEN) is a rare, acute mucocutaneous life-threatening disease. Although research has focused on the pathophysiological and therapeutic aspects of the disease, there is a paucity of data in the literature regarding pain management and sedation in the intensive care unit (ICU). Most therapies have been extrapolated from other situations and/or the general ICU population.

Shear Wave Speed estimator using Continuous Wavelet Transform for Crawling Wave Sonoelastography.

Crawling Wave Sonoelastography (CWS) is an elastography ultrasound-based imaging approach that provides tissue stiffness information through the calculation of Shear Wave Speed (SWS). Many SWS estimators have been developed; however, they report important limitations such as the presence of artifacts, border effects or high computational cost. In addition, these techniques require a moving interference pattern which could be challenging for in vivo applications.

Modified Regularized Wavelength Average Velocity Estimator for normal excitation setup.

Crawling Waves Sonoelastography (CWS) is an ultrasound elastography approach for the Shear Waves Speed (SWS) estimation. Several studies show promising results for tissue characterization. The algorithms used to calculate the SWS have been commonly implemented considering an opposing vibration sources to the side of the tissue of interest.