Publications by authors named "Sebastian Meisner"
Article Synopsis
- The study explored the long-term effects of donor-specific human leukocyte antigen (HLA) class 2 antibodies (DSA cl 2) on liver transplant recipients, involving 156 participants (44 pediatric and 112 adult).
- Nearly half (46%) of recipients tested positive for DSA cl 2 after an average follow-up of 15 years, which was linked to higher levels of graft fibrosis and a greater incidence of chronic rejection compared to DSA cl 2 negative patients.
- The findings suggest that the presence of DSA cl 2 is associated with immunosuppressive monotherapy, leading to worse outcomes like increased graft fibrosis and the risk of graft loss.
Purpose: In order to assess the occurrence of blood congestion in the liver during liver resection, we aimed to evaluate the influence of a positive-end-expiratory-pressure (PEEP) and positioning of patients on central venous pressure (CVP) and venous hepatic blood flow parameters. We further analyzed correlations between CVP and venous hepatic blood flow parameters.
Methods: In 20 patients scheduled for elective liver resection we measured CVP and quantified venous hepatic hemodynamics by ultrasound assessment of flow-velocity and diameter of the right hepatic vein and the portal vein after equilibration following these maneuvers: M1: 0° supine position, PEEP 0 cmHO; M2: 0° supine position, PEEP 10 cmHO; M3: 20° reverse-trendelenburg position; PEEP 10 cmHO; M4: 20° reverse-trendelenburg position, PEEP 0cmHO.