Publications by authors named "Sebastian Klomfass"
Article Synopsis
- The study investigates the relationship between aortic stenosis (AS) and calcium/bone metabolism by analyzing parameters in patients with severe AS compared to control subjects.
- Patients with AS showed significantly higher levels of serum calcium and phosphate, as well as increased calcium-phosphorus products, indicating a disruption in mineral balance.
- Additionally, lower levels of intact parathyroid hormone (iPTH) and elevated osteoprotegerin in the AS group suggest altered hormonal regulation related to calcium and bone metabolism in this condition.
Background And Aim Of The Study: Calcific aortic stenosis (AS) is the most frequently acquired valvular disease of the elderly in the Western world. A genetic background for AS has been proposed. The deposition of calcium hydroxyapatite is the key problem of valve calcification; vitamin D and parathyroid hormone are major factors in calcium homeostasis.
View Article and Find Full Text PDFCalcific aortic valve stenosis, the most frequent heart valve disorder in developed countries, is an actively regulated process with similarities to bone formation. Fetuin-A has recently been identified as a potent circulating inhibitor of calcification. While several studies involving patients with end-stage renal disease have shown an association between low serum fetuin-A and cardiovascular calcification, nothing is known about fetuin-A serum levels in non-renal patients with calcific aortic valve stenosis.
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