Publications by authors named "Sebastian Hartenstein"
Article Synopsis
- Pontine tegmental cap dysplasia is a rare brain malformation affecting the hindbrain, characterized by a small pons and issues with cranial nerves, leading to various neurological symptoms.
- This report details the case of an extremely low-birth-weight preterm infant, the first known case with this syndrome born at just 25 weeks of gestation, and discusses findings from 29 other cases.
- The infant showed severe muscle weakness and unusual painful episodes that included muscle spasms and facial tics, contributing new details to the understanding of this condition.
Besides remarkable improvements of neonatal medical therapy, neurological morbidity remains a major concern in preterm infants. In particular, intracranial hemorrhage is a severe complication strongly correlated to poor neurological outcome. For early clinical assessment of intracranial hemorrhage and its impact on the ventricular system, cranial sonography is an important bedside diagnostic tool.
View Article and Find Full Text PDFAs an alternative to surfactant therapy (ST), partial liquid ventilation (PLV) with perfluorocarbons (PFC) has been considered as a treatment for acute lung injury (ALI) in newborns. The instilled PFC is much heavier than the instilled surfactant and the aim of this study was to investigate whether PLV, compared to ST, increases the end-expiratory volume of the lung (VL). Fifteen newborn piglets (age <12 h, mean weight 678 g) underwent saline lung lavage to achieve a surfactant depletion.
View Article and Find Full Text PDFProteomic analysis of midtrimester amniotic fluid to identify novel biomarkers for preterm delivery.
J Matern Fetal Neonatal Med
December 2012
Objective: The aim of this study was to identify possible biomarkers for preterm delivery by analyzing midtrimester amniotic fluid.
Methods: Thirty-two amniotic fluid samples were studied; 16 patients had a spontaneous preterm delivery and 16 patients delivered at term. The proteomic technique consisted of surface-enhanced laser desorption ionization time-of-flight (SELDI-TOF) using different types of solid chromatographic chips (Q10, CM10 and IMAC30).