[Efficaccy of probiotic in the treatment of small intestinal bacterial overgrowth. Systematic review and meta-analysis].

Introduction: Conventional management of small intestinal bacterial overgrowth (SIBO) involves intraluminal-action antibiotics. Controversially, probiotics are used to optimize outcomes, but this therapeutic intervention is understudied.

Objective: To evaluate the efficacy of probiotics in the treatment of small intestinal bacterial overgrowth.

[Development and validation of a diagnostic model of antimicrobial resistance by extended-spectrum beta-lactamases in community-acquired urinary tract infections. How to adjust the prediction in variable outcome prevalences? The usefulness of contracting predictors with LASSO regression].

Background: In the case of community-acquired urinary tract infection, the identification of Enterobacteriaceae with extended spectrum beta-lactamases (ESBL) can optimize treatment, control and follow-up strategies, however the effect of variable prevalences of this resistance pattern has affected the external validity of this type of models.

Aim: To develop a diagnostic predictive model that adjusts the prediction error in variable prevalences using the LASSO regression.

Methods: A diagnostic predictive model of community-acquired urinary tract infection by infection by ESBL producing Enterobacteriaceae was designed.