Publications by authors named "Sebastian Elmer"
Article Synopsis
- A seroepidemiological study in Tyrol, Austria, assessed SARS-CoV-2 antibody seropositivity among over 5,300 blood donors, revealing a 3.1% seroprevalence, significantly higher than reported case numbers.
- The study found higher seroprevalence in the Landeck district (16.6%) and among individuals under 25 years of age, with travel to specific areas increasing the odds of seropositivity.
- Participants who tested positive for antibodies more often reported symptoms like loss of smell and taste compared to those with suspected infections but negative antibody tests, highlighting the relevance of serological testing.
The cytochrome P450 (CYP) superfamily represents the major enzyme class responsible for the metabolism of exogenous compounds. Investigation of clearance pathways is therefore an integral part in early drug development, as any alteration of metabolic enzymes may markedly influence the toxicological profile and efficacy of novel compounds. In silico methods are widely applied in drug development to complement experimental approaches.
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