Publications by authors named "Sebastian Cruz Gonzalez"
Article Synopsis
- Physical activity improves symptoms in people with systemic lupus erythematosus (SLE), but the underlying mechanisms were unclear until this study explored immune cell differences among active vs. inactive patients.
- A cohort of 123 SLE patients underwent analysis of immune cells and gene expression through advanced RNA sequencing, revealing that sedentary patients had greater CD4+ T cell lymphopenia and an overall proinflammatory gene expression profile.
- The study indicates that increased physical activity could reduce levels of proinflammatory cytokines and improve immune function in SLE patients, suggesting potential therapeutic benefits of regular exercise for this condition.
Article Synopsis
- Epigenetic clocks measure aging rates through DNA methylation patterns and could help predict age-related diseases like Alzheimer's, but lack validation in genetically diverse groups.* -
- A study evaluated these clocks in 621 Alzheimer's patients and controls from African American, Hispanic, and white backgrounds, revealing reduced accuracy in those with mixed ancestries, particularly with substantial African heritage.* -
- The findings indicate that methylation-related genetic variations (meQTL) are more common in individuals of African ancestry, highlighting the need for improvements to make these clocks more effective across diverse populations.*
Injury to the central nervous system (CNS) results in permanent damage and lack of function in most vertebrate animals, due to their limited regenerative capacities. In contrast, echinoderms can fully regenerate their radial nerve cord (RNC) following transection, with little to no scarring. Investigators have associated the regenerative capacity of some organisms to the stress response and inflammation produced by the injury.
View Article and Find Full Text PDFEchinoderms comprise a group of animals with impressive regenerative capabilities. They can replace complex internal organs following injury or autotomy. In holothurians or sea cucumbers, cellular processes of intestinal regeneration have been extensively studied.
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