Publications by authors named "Sebastian Botzenhardt"
Article Synopsis
- - This study examines the effects of a computerized physician order entry (CPOE) system on reducing adverse drug events (ADEs) and potentially harmful medication errors (pot ADEs) in a pediatric ward compared to traditional paper records.
- - Conducted over five months, the research involved reviewing charts of patients aged 17 and younger to assess medication-related issues and classify them into various categories, including ADEs and medication errors.
- - Results showed that while 2.7% of patients experienced an ADE in the paper-based system, this was similar in the electronic system (2.8%), but the number of potentially harmful medication errors significantly decreased from an average of 1.69 per patient to 0.71 with
Pharmacotherapy of neonates is complex and marked to a large extent of off-label use. The implementation of the Paediatric Regulation (2007) gave hope for a change in the safety and efficacy for drugs used in neonatal intensive care units (NICU). This study investigates drug utilisation patterns and off-label use in a German neonatal intensive care unit (NICU) in 2014.
View Article and Find Full Text PDFBackground: This review describes the safety of deferoxamine (DFO), deferiprone (DFP), deferasirox (DFX) and combined therapy in young patients less than 25 yr of age with haemoglobinopathies.
Methods: Searches in electronic literature databases were performed. Studies reporting adverse events associated with iron chelation therapy were included.
Aim: Analgesic and anti-inflammatory drugs are frequently prescribed in paediatrics. Prescribing and dosing patterns in hospitalised children are not well known. This study explores analgesic drug utilisation on five paediatric wards and discusses its findings in comparison with World Health Organization (WHO) guidelines.
View Article and Find Full Text PDFUnlabelled: There is a lack of knowledge regarding the incidence of serious adverse drug reactions (ADR) to the oral iron chelator deferiprone in Chinese children with transfusion-dependent thalassaemia. In this retrospective population-based cohort study, paediatric thalassaemia patients in Hong Kong were screened for serious and medically important adverse events related to deferiprone therapy using diagnosis codes, laboratory data and hospital admissions. Potential ADRs were assessed by reviewing concomitant medications, diagnoses and laboratory data and evaluated using standardised causality assessment.
View Article and Find Full Text PDF