Publications by authors named "Sebastian B B Bon"
Article Synopsis
- The study examines the effectiveness of two methods for identifying cancer predisposition syndromes (CPS) in children with newly diagnosed cancers in a Dutch pediatric oncology center.
- Out of 1052 eligible children, 733 underwent both a phenotype-driven approach and a broader phenotype-agnostic gene sequencing, identifying 53 cases of CPS.
- The phenotype-agnostic method revealed more CPS cases, demonstrating that broad genetic sequencing can be more effective than clinical selection based solely on symptoms.
This study explored the experiences and needs of adolescents, ranging from 12 to 18 years old, who have recently been diagnosed with cancer and participated in a nationwide germline genetic sequencing study within the context of pediatric oncology. The 21 adolescents in this qualitative interview study viewed genetic sequencing as an integral part of their cancer journey. They often characterized germline sequencing as "good-to-know" without specifying immediate utility.
View Article and Find Full Text PDFObjective: In pediatric oncology, large-scale genetic sequencing contributes to the identification of cancer predisposition, which can facilitate surveillance and family counseling. Our qualitative study explores families' motives, knowledge, and views regarding germline genetic sequencing to improve future counseling and support.
Methods: Semi-structured interviews were conducted with parents of children with renal tumors participating in a national center, germline sequencing study.