Publications by authors named "Seb Marcuccio"
Endocrinology
January 2007
Article Synopsis
- Olomoucine inhibits insulin's stimulation of glucose transport without affecting other insulin signaling proteins.
- Researchers created analogs of olomoucine that are more effective at blocking insulin-stimulated glucose uptake, with the most effective analog having an IC50 of 0.1 microM.
- The study identified calcium/calmodulin-dependent protein kinase II (CaMKII) as a key player, where a mutant version of CaMKII significantly reduced insulin-stimulated glucose transport by around 80%, but did not affect GLUT4 translocation.
