Publications by authors named "Seayar Mohabbat"
Article Synopsis
- Advances in single-cell and spatial technologies are enhancing our ability to analyze gene expression in clinical tissue samples, particularly in breast cancer.
- By integrating various gene expression profiling techniques, researchers investigated molecular differences within tumor regions and identified key biomarkers linked to cancer progression.
- The study highlights that while each technology offers valuable data individually, their combined use reveals deeper insights into cancer heterogeneity, potentially influencing future research and treatment strategies in oncology.
Salivary gland acinar cells are severely depleted after radiotherapy for head and neck cancer, leading to loss of saliva and extensive oro-digestive complications. With no regenerative therapies available, organ dysfunction is irreversible. Here, using the adult murine system, we demonstrate that radiation-damaged salivary glands can be functionally regenerated via sustained delivery of the neurogenic muscarinic receptor agonist cevimeline.
View Article and Find Full Text PDFAcinar cells are the principal secretory units of multiple exocrine organs. A single-cell, layered, lumenized acinus forms from a large cohort of epithelial progenitors that must initiate and coordinate three cellular programs of acinar specification, namely, lineage progression, secretion, and polarization. Despite this well-known outcome, the mechanism(s) that regulate these complex programs are unknown.
View Article and Find Full Text PDF