Know Before You Go: Data-Driven Beach Water Quality Forecasting.

Forecasting environmental hazards is critical in preventing or building resilience to their impacts on human communities and ecosystems. Environmental data science is an emerging field that can be harnessed for forecasting, yet more work is needed to develop methodologies that can leverage increasingly large and complex data sets for decision support. Here, we design a data-driven framework that can, for the first time, forecast bacterial standard exceedances at marine beaches with 3 days lead time.

Curriculum Vitae Workshops: Promoting Transparency in Alpha Omega Alpha While Serving Student Needs.

Objective: To promote equity in the Alpha Omega Alpha Honor Medical Society (AOA) selection process, clear and timely communication of eligibility criteria is needed. Herein, the authors describe and assess the effectiveness of a novel method for improving transparency in the AOA selection process while also teaching students key professional development skills.

Methods: The authors hosted curriculum vitae (CV) workshops for interested medical students.

A Day at the Beach: Enabling Coastal Water Quality Prediction with High-Frequency Sampling and Data-Driven Models.

To reduce the incidence of recreational waterborne illness, fecal indicator bacteria (FIB) are measured to assess water quality and inform beach management. Recently, predictive FIB models have been used to aid managers in making beach posting and closure decisions. However, those predictive models must be trained using rich historical data sets consisting of FIB and environmental data that span years, and many beaches lack such data sets.

Early Termination of Cardiac Rehabilitation Is More Common With Heart Failure With Reduced Ejection Fraction Than With Ischemic Heart Disease.

Purpose: Despite known benefits of cardiac rehabilitation (CR), early termination (failure to complete >1 mo of CR) attenuates these benefits. We analyzed whether early termination varied by referral indication in the context of recent growth in patients referred for heart failure with reduced ejection fraction (HFrEF).

Methods: We reviewed records from 1111 consecutive patients enrolled in the NYU Langone Health Rusk CR program (2013-2017).

IL35 Hinders Endogenous Antitumor T-cell Immunity and Responsiveness to Immunotherapy in Pancreatic Cancer.

Although successes in cancer immunotherapy have generated considerable excitement, this form of treatment has been largely ineffective in patients with pancreatic ductal adenocarcinoma (PDA). Mechanisms that contribute to the poor antitumor immune response in PDA are not well understood. Here, we demonstrated that cytokine IL35 is a major immunosuppressive driver in PDA and potentiates tumor growth via the suppression of endogenous antitumor T-cell responses.

Evaluation of sedation-related medication errors in patients on contact isolation in the intensive care unit.

Background: Patients in intensive care units (ICUs) may be placed on contact isolation for meticillin-resistant Staphylococcus aureus (MRSA) colonization to prevent transmission. Prior studies suggest that isolated patients may receive substandard care compared with non-isolated patients. An optimal level of sedation is required to facilitate mechanical ventilation (MV) and to minimize adverse outcomes.

Evaluation of Neuroleptic Utilization in the Intensive Care Unit During Transitions of Care.

Purpose: The purpose of this study was to identify risk factors associated with inappropriate continuation of neuroleptics postdischarge from the intensive care unit (ICU) and hospital.

Materials And Methods: A retrospective chart review was performed including all patients greater than 18 years of age who received neuroleptic medications in an ICU.

Results: One hundred sixty-one patients were included during the 12- month study period.

The role of inhaled prostacyclin in treating acute respiratory distress syndrome.

Acute respiratory distress syndrome (ARDS) is a syndrome of acute lung injury that is characterized by noncardiogenic pulmonary edema and severe hypoxemia second to a pathogenic impairment of gas exchange. Despite significant advances in the area, mortality remains high among ARDS patients. High mortality and a limited spectrum of therapeutic options have left clinicians searching for alternatives, spiking interest in selective pulmonary vasodilators (SPVs).

Captive reproduction of the Jamaican iguana (Cyclura collei).

The Jamaican iguana (Cyclura collei) was considered to be extinct until its rediscovery in 1990 in the Hellshire Hills region of Jamaica. Between 1994 and 1996, several wild caught juveniles were placed in six North American zoological institutions including the Indianapolis Zoo. The intent was to establish a self-sustaining captive population outside of Jamaica in order to serve as an ancillary population should the wild numbers decline.

Effects of tidal volume and respiratory frequency on lung lymph flow.

Ventilation (V) increases lung lymph flow (Ql), but the separate effects of tidal volume (Vt) and frequency (f) and the role of V-induced changes in edema formation are poorly understood. An isolated, in situ sheep lung preparation was used to examine these effects. In eight sheep with f = 10 min(-1), results obtained during 30-min periods with Vt = 5 or 20 ml/kg were compared with values obtained during bracketed 30-min control periods (Vt = 12.

Homeopathic terminology: a consensus quest.

The aim of this project is to develop a common homeopathic terminology to improve communication. A questionnaire was sent by email to an international group of experts. As a result of an iterative process we propose that a number of terms which are inaccurate, unclear or have become outdated should be replaced by new terms.

A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice.

nkx-2.5 is one of the first genes expressed in the developing heart of early stage vertebrate embryos. Cardiac expression of nkx-2.

Analysis of Hox gene expression during early avian heart development.

The anteroposterior (A-P) patterning of the developing heart underlies atrial and ventricular lineage specification and heart chamber morphogenesis. The posteriorization of cardiomyogenic phenotype with retinoic acid (RA) treatment of primitive streak stage chicken embryos is suggestive of a role for the clustered homeobox (Hox) genes in early heart patterning (Yutzey et al. [1994] Development 120:871-873; [1995] Dev.

Ménétrièr's disease and idiopathic hypertrophic gastropathy.

The cases of 43 patients with hypoproteinemic hypertrophic gastropathy (Ménétrièr's disease) seen at the Mayo Clinic during 1970 to 1980 are reviewed. Characteristically, patients with Ménétrièr's disease are older than 60 years of age and have epigastric pain, weight loss, nausea, diarrhea, and dyspepsia, with or without a history of peptic ulcer disease. Ménétrièr's disease can be associated with swelling in the extremities, vomiting and early satiety, maculopapular rash, anorexia, and fatigue.

The deleterious effects of high dose cimetidine in acute thermal injury.

Pharmacological doses of cimetidine have been reported to reduce oedema formation in murine burn models. Sprague-Dawley rats subjected to a 30 per cent full-thickness burn were treated with cimetidine (200 mg/kg) pre and post burn. Untreated, burned animals and sham-burned animals were also studied.

Clinical evaluation of sodium amylosulfate in human blood cultures.

Sodium amylosulfate was shown to be a useful anticoagulant additive for increased isolation of bacteria from clinical blood cultures.