Joint quantile regression of longitudinal continuous proportions and time-to-event data: Application in medication adherence and persistence.

This study introduces a novel joint modeling framework integrating quantile regression for longitudinal continuous proportions data with Cox regression for time-to-event analysis, employing integrated nested Laplace approximation for Bayesian inference. Our approach facilitates an examination across the entire distribution of patient health metrics over time, including the occurrence of key health events and their impact on patient outcomes, particularly in the context of medication adherence and persistence. Integrated nested Laplace approximation's fast computational speed significantly enhances the efficiency of this process, making the model particularly suitable for applications requiring rapid data analysis and updates.

A Preliminary Study on the Siphon Mechanism in Giraffe ().

Adult giraffes reach heights of 4.5 m with a heart-to-head distance of over 2 m, making cranial blood supply challenging. Ultrasound confirmed that the giraffe jugular vein collapses during head movement from ground level to fully erect, negating the possibility of a siphon mechanism in the neck.

A robust method for the assessment of average bioequivalence in the presence of outliers and skewness.

Purpose: In this paper, we propose a robust Bayesian method for the assessment of average bioequivalence based on data from conventional crossover studies. We evaluate and motivate empirically the need for robust methods in bioequivalence studies by comparing the results of robust and conventional statistical methods in a large data pool of bioequivalence studies.

Methods: Robustness of the statistical methodology is achieved by replacing the normal distributions for residuals in the linear mixed model with skew-t distributions.

Anthropogenic Influences on Distance Traveled and Vigilance Behavior and Stress-Related Endocrine Correlates in Free-Roaming Giraffes.

Giraffes are an important tourist attraction, and human presence to wildlife is increasing. This has an impact on an animal's behavior and its endocrine correlates. Studies on other species show alterations in movement patterns, vigilance, and stress-related hormone levels in the presence of humans.