A Survey of Current Gonioscopy Practice in the United Kingdom.

Prcis: This survey highlights a deficiency in gonioscopy practices across the UK, particularly in the utilization of indentation gonioscopy and training of junior ophthalmologists. Recommendations include standardizing practice and enhancing training opportunities to improve patient care.

Objective: Gonioscopy is an important general skill learned and practiced by all grades of ophthalmologists.

Large language models approach expert-level clinical knowledge and reasoning in ophthalmology: A head-to-head cross-sectional study.

Large language models (LLMs) underlie remarkable recent advanced in natural language processing, and they are beginning to be applied in clinical contexts. We aimed to evaluate the clinical potential of state-of-the-art LLMs in ophthalmology using a more robust benchmark than raw examination scores. We trialled GPT-3.

COVID-19-associated mixed cilioretinal artery occlusion and central venous occlusion in a fit and healthy young patient.

Retinal artery occlusion is an unusual phenomenon in younger patients without background of diseases leading to hypercoagulable states. COVID-19 infection is increasingly recognised as being associated with thrombotic conditions. We present a case of a young female who is otherwise fit and well apart from recent COVID-19 infection, who presented with a mixed cilioretinal artery and venous occlusion.

Erdheim-Chester Disease: Two cases from an ophthalmic perspective.

Purpose: We report two patients who presented initially to ophthalmology clinics with symptoms and signs of orbital inflammation that led to a diagnosis of Erdheim-Chester Disease (ECD).

Observations: ECD is a rare form of non-Langerhans cell histiocytosis (LCH) which is characterised by multi-system organ involvement and poor prognosis with standard therapies. Both patients were positive for the V600E mutation on genetic testing and were treated with the inhibitors Vemurafenib and Dabrafenib respectively.

The delineation of largely deformed brain midline using regression-based line detection network.

Purpose: The human brain has two cerebral hemispheres that are roughly symmetric and separated by a midline, which is nearly a straight line shown in axial computed tomography (CT) images in healthy subjects. However, brain diseases such as hematoma and tumors often cause midline shift, where the degree of shift can be regarded as a quantitative indication in clinical practice. To facilitate clinical evaluation, we need computer-aided methods to automate this quantification.

Suppression of with observed inhaled corticosteroid therapy in severe asthma: is it a useful test in clinical practice?

http://bit.ly/35oSoxP.

Background correction for cDNA microarray images using the TV+L1 model.

Motivation: Background correction is an important preprocess in cDNA microarray data analysis. A variety of methods have been used for this purpose. However, many kinds of backgrounds, especially inhomogeneous ones, cannot be estimated correctly using any of the existing methods.