Publications by authors named "Sean Y Huang"
Article Synopsis
- The study introduces a new assay called PReCIS-seq to analyze how RNA Polymerase II activity is regulated in specific cell lineages within intact mouse tissues.
- Using keratinocytes as a model, researchers explore the processes of promoter recruitment and pause-release of Pol II, particularly in the context of adult skin homeostasis.
- The findings show that Pol II activity differs depending on gene function, with rapid transcription for lineage-specific genes and increased pausing for genes involved in cellular protection, providing insights into gene regulation in complex tissues.
