Initial Experience with Topical Fluorouracil for Treatment of HIV-Associated Anal Intraepithelial Neoplasia.

Exposure to high-risk strains of human papillomavirus (HPV) promotes cellular dysplasia of the anal canal epithelium, potentially leading to anal intraepithelial neoplasia (AIN), which is in turn a precursor to invasive squamous cell carcinoma of the anus (SCCA). People with HIV infection who engage in anoreceptive intercourse are at heightened risk for acquiring HPV, AIN, and SCCA. Although intravenous 5-fluorouracil (5-FU) is commonly used for treatment of invasive SCCA, there has been little experience with the use of topical 5-FU as therapy for AIN.

Tunable photochromism of spirooxazines via metal coordination.

Through the incorporation of a phenanthroline ligand into the oxazine moiety of photochromic spirooxazines, a series of photochromic spirooxazine-phenanthroline metal complexes have been synthesized, resulting in tunable and significantly increased photoresponsivities. Such systems are of interest for the investigation of multifunctional photochromic materials. These novel metal complexes retain their photochromic activity in the complexed state, leading to ligand binding in both the spirooxazine and the photomerocyanine forms during the photoconversion.