Publications by authors named "Sean M Bennet"
Article Synopsis
- - The study investigates how dietary changes, specifically reducing fermentable carbohydrates, can alleviate pain in patients with irritable bowel syndrome (IBS) and how it relates to gut microbiota and neuroactive substances.
- - Participants followed a diet that alternated between low and high fermentable carbohydrates, while their symptoms, stool samples, and nerve reactions were monitored to assess the impact of these diets.
- - Results showed that a low-fermentable diet significantly reduced IBS symptoms and altered the activity of nerve cells, indicating that dietary changes may influence pain signaling through the gut's biochemicals.
Application of metabolomics to the study of irritable bowel syndrome.
Neurogastroenterol Motil
June 2020
Article Synopsis
- The pathophysiology of irritable bowel syndrome (IBS) is complex and varies widely among patients, making it difficult to identify specific biomarkers for diagnosis and treatment.
- Recent studies suggest that differences in diet and microbiome interactions may trigger symptoms in some individuals with IBS, highlighting the importance of understanding these factors.
- The review discusses the use of metabolomics, particularly nuclear magnetic resonance (NMR) techniques, to analyze small molecules in the body that could help reveal the mechanisms of IBS and predict treatment responses.
Article Synopsis
- The study aimed to explore the differences in cytokine profiles between patients with irritable bowel syndrome (IBS) and healthy individuals, as well as the relationship between cytokine levels and the severity of IBS symptoms.
- The analysis involved serum and tissue samples from both groups, focusing on various cytokines; results showed overlapping cytokine profiles but greater variability in IBS patients, with some markers linked to symptom patterns.
- Despite no distinct cytokine profiles separating IBS patients from healthy subjects, a subgroup of IBS patients with elevated immune markers was identified, highlighting potential areas for further research.
Irritable bowel syndrome (IBS) is a multifactorial functional disorder with no clearly defined etiology or pathophysiology. Modern culture-independent techniques have improved the understanding of the gut microbiota's composition and demonstrated that an altered gut microbiota profile might be found in at least some subgroups of IBS patients. Research on IBS from a microbial perspective is gaining momentum and advancing.
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