Publications by authors named "Sean Lee Qiu En"
Octacosamicin A is an antifungal metabolite featuring a linear polyene-polyol chain flanked by N-hydroxyguanidine and glycine moieties. We report here that sub-inhibitory concentrations of streptomycin elicited the production of octacosamicin A in Amycolatopsis azurea DSM 43854 . We identified the biosynthetic gene cluster (oca BGC) that encodes a modular polyketide synthase (PKS) system for assembling the polyene-polyol chain of octacosamicin A.
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- A new group of cyclic lipopeptides, tasikamides A-H (Tsk A-H), were discovered in a strain of bacteria called Streptomyces tasikensis P46, which have a unique cyclic pentapeptide structure.
- Tasikamides I-K (Tsk I-K) were produced by a genetically modified version of the same strain, featuring a different type of bridge (enaminone-bridge) that connects the cyclic peptide to a lipid component.
- The study revealed that Tsk I-K are formed through a nonenzymatic condensation reaction involving two biosynthetic pathways, highlighting the chemical reactivity of specific molecules in bacteria during these processes.