Publications by authors named "Sean Lafata"
Background: Predicting fibrostenotic complications prior to endoscopy in eosinophilic esophagitis (EoE) is challenging and esophageal strictures and narrowing are commonly missed on endoscopy.
Aim: To develop and validate a score to predict fibrostenosis in EoE patients prior to endoscopy.
Methods: We leveraged a large database of newly diagnosed EoE patients.
Daily or Twice Daily Treatment with Topical Steroids Results in Similar Responses in Eosinophilic Esophagitis.
Clin Gastroenterol Hepatol
November 2024
Background & Aims: Few data compare topical corticosteroid (tCS) dosing regimens and outcomes. We aimed to compare treatment outcomes in patients with eosinophilic esophagitis (EoE) by once or twice daily dosing regimens.
Methods: We conducted a retrospective cohort study using the UNC EoE Clinicopathologic Database of newly diagnosed patients with EoE treated with a tCS who had a follow-up endoscopy with biopsy.
Goals: To determine long-term efficacy and safety of tCS for treatment of EoE.
Background: Maintenance therapy with topical corticosteroids (tCS) is recommended for eosinophilic esophagitis (EoE), but data for long-term use are still needed.
Study: This retrospective cohort study assessed newly diagnosed patients with EoE who were treated with a tCS and had a follow-up endoscopy with biopsy after at least 5 years.
Article Synopsis
- Cannabis use is rising among people for both recreational and medical reasons, but there isn't much research on its effects in eosinophilic esophagitis (EoE).
- A study involved 983 newly diagnosed EoE patients, with 80 reporting cannabis use, mainly through inhalation and daily consumption.
- Findings indicated that cannabis users had milder initial symptoms but showed worse inflammatory responses after treatment compared to non-users, suggesting that cannabis may negatively affect EoE management.
Background: The presentation of eosinophilic esophagitis (EoE) is heterogeneous, but trends over time are not known.
Aim: To determine whether clinical and endoscopic phenotypes at EoE diagnosis have changed over the past 2 decades.
Methods: In this retrospective cohort study, adults and children with newly diagnosed EoE were phenotyped as follows: (1) inflammatory vs fibrostenotic vs mixed on endoscopy; (2) atopic vs non-atopic; (3) age at symptom onset; (4) age at diagnosis; (5) presence of autoimmune or connective tissue disease; and (6) responsive to steroids.
Objectives: Feeding tubes can provide a temporary or long-term solution for nutritional therapy. Little is known regarding the use of feeding tubes in patients with eosinophilic esophagitis (EoE). We sought to describe the characteristics and outcomes in EoE patients requiring tube feeding.
View Article and Find Full Text PDFEffect of Proton Pump Inhibitor Treatment in "PPI Non-responsive" Patients with Eosinophilic Esophagitis.
J Gastrointestin Liver Dis
March 2023
Background And Aims: Some eosinophilic esophagitis (EoE) patients can have a decline in eosinophil count after proton pump inhibitor (PPI) treatment without achieving histologic response, but little is known about this group. We aimed to determine the effect of PPIs on reducing esophageal eosinophilia in patients deemed non-responsive to PPI therapy.
Methods: We analyzed prospectively collected cohort data from newly diagnosed adults with EoE who were histologic non-responders (≥15 eos/hpf) to PPI-only therapy.