Publications by authors named "Sean I Young"

Blood oxygen level dependent (BOLD) MRI time series with maternal hyperoxia can assess placental oxygenation and function. Measuring precise BOLD changes in the placenta requires accurate temporal placental segmentation and is confounded by fetal and maternal motion, contractions, and hyperoxia-induced intensity changes. Current BOLD placenta segmentation methods warp a manually annotated subject-specific template to the entire time series.

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Interpretability for machine learning models in medical imaging (MLMI) is an important direction of research. However, there is a general sense of murkiness in what interpretability means. Why does the need for interpretability in MLMI arise? What goals does one actually seek to address when interpretability is needed? To answer these questions, we identify a need to formalize the goals and elements of interpretability in MLMI.

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Article Synopsis
  • The text discusses open-source tools designed for 3D analysis of photographs from dissected human brain slices, which are often underutilized for quantitative studies.
  • These tools can reconstruct a 3D volume and segment brain images into 11 regions per hemisphere, serving as a cost-effective alternative to traditional MRI imaging.
  • Testing shows that the methodology provides accurate 3D reconstructions and can differentiate between Alzheimer's disease cases and healthy controls, with tools available in the FreeSurfer suite.
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Learning-based image reconstruction models, such as those based on the U-Net, require a large set of labeled images if good generalization is to be guaranteed. In some imaging domains, however, labeled data with pixel- or voxel-level label accuracy are scarce due to the cost of acquiring them. This problem is exacerbated further in domains like medical imaging, where there is no single ground truth label, resulting in large amounts of repeat variability in the labels.

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Article Synopsis
  • Open-source tools have been developed for 3D analysis of brain slice photographs, which are often underutilized for quantitative research.
  • These tools can 3D reconstruct brain volumes and segment them into 22 regions, independent of slice thickness, serving as a viable alternative to costly MRI scans.
  • Tests on data from Alzheimer's Disease Research Centers show that the tools provide accurate reconstructions and detect differences related to Alzheimer's, with results comparable to those obtained from MRI.
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In recent years, learning-based image registration methods have gradually moved away from direct supervision with target warps to instead use self-supervision, with excellent results in several registration benchmarks. These approaches utilize a loss function that penalizes the intensity differences between the fixed and moving images, along with a suitable regularizer on the deformation. However, since images typically have large untextured regions, merely maximizing similarity between the two images is not sufficient to recover the true deformation.

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In this paper, we compress convolutional neural network (CNN) weights post-training via transform quantization. Previous CNN quantization techniques tend to ignore the joint statistics of weights and activations, producing sub-optimal CNN performance at a given quantization bit-rate, or consider their joint statistics during training only and do not facilitate efficient compression of already trained CNN models. We optimally transform (decorrelate) and quantize the weights post-training using a rate-distortion framework to improve compression at any given quantization bit-rate.

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We propose the fast optical flow extractor, a filtering method that recovers artifact-free optical flow fields from HEVCcompressed video. To extract accurate optical flow fields, we form a regularized optimization problem that considers the smoothness of the solution and the pixelwise confidence weights of an artifactridden HEVC motion field. Solving such an optimization problem is slow, so we first convert the problem into a confidence-weighted filtering task.

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Recently, many fast implementations of the bilateral and the nonlocal filters were proposed based on lattice and vector quantization, e.g. clustering, in higher dimensions.

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This paper proposes graph Laplacian regularization for robust estimation of optical flow. First, we analyze the spectral properties of dense graph Laplacians and show that dense graphs achieve a better trade-off between preserving flow discontinuities and filtering noise, compared with the usual Laplacian. Using this analysis, we then propose a robust optical flow estimation method based on Gaussian graph Laplacians.

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We address the problem of decoding joint photographic experts group (JPEG)-encoded images with less visual artifacts. We view the decoding task as an ill-posed inverse problem and find a regularized solution using a convex, graph Laplacian-regularized model. Since the resulting problem is non-smooth and entails non-local regularization, we use fast high-dimensional Gaussian filtering techniques with the proximal gradient descent method to solve our convex problem efficiently.

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