Publications by authors named "Sean Golinski"
Article Synopsis
- * Researchers found that the channel's activity increases with age and identified abnormal neuron behavior due to a specific KCNT1 mutation (p.R474H) associated with these conditions.
- * A clinical trial showed that an antisense oligonucleotide (ASO) therapy significantly reduced seizures in individuals with the mutation, and it’s possible to target the K1.1 channel early in brain development for therapeutic intervention.
Background And Objectives: Falls, the leading cause of death and disability among older adults, occur in daily life when the demands of daily activities surpass the ability to maintain balance. An estimated 30% of older adults misestimate their physical function, placing them at greater risk of falling. This study examined how experiences of physical function are linked to awareness of fall risk in daily life.
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