Comparison of TRho MRI, Glucose Metabolism, and Amyloid Burden Across the Cognitive Spectrum: A Pilot Study.

Objective: The pathological cascades associated with the development of Alzheimer's disease (AD) have a common element: acidosis. Trho MRI is a pH-sensitive measure, with higher values associated with greater neuropathological burden. The authors investigated the relationship between Trho imaging and AD-associated pathologies as determined by available diagnostic imaging techniques.

Early Phase PIB-PET as a Surrogate for Global and Regional Cerebral Blood Flow Measures.

Background And Purpose: To explore the potential for simplified measures of [ C]PIB uptake to serve as a surrogate for cerebral blood flow (CBF) measures, thereby, providing both pathological and functional information in the same scan.

Methods: Participants (N = 24, 16 M, 8 F, 57-87 years) underwent quantitative [ O]water imaging and dynamic [ C]PIB imaging. Time-activity curves were created for each participant's regional [ C]PIB data scaled in standardized uptake values (SUVs).