Publications by authors named "Sean C Engel"

Injury rates among gymnasts are among the highest of any sport at the high school and collegiate level per athletic exposure. The wrist has increased injury risk due to repetitive physical stresses predisposing it to acute injury, overuse, and degenerative damage. This article will review the most common overuse wrist injuries seen in gymnasts.

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CPR for drowning survivors differs from that commonly used in cardiogenic cardiac arrest. Routine antibiotic prophylaxis is not indicated.

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Background: The contribution of scapulothoracic and glenohumeral motion to overall shoulder motion remains difficult to determine. We sought to determine the exact ratio between these two motion components in order to better understand overall shoulder kinematics in asymptomatic individuals in unconstrained reaching.

Materials And Methods: This study assessed shoulder motion using bone-fixed sensors to quantify scapulohumeral motion during unconstrained raising and lowering of the arm.

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Article Synopsis
  • Disruption of the 9p21 locus in mesothelioma commonly leads to the loss of p16INK4a and p14ARF, prompting research into the potential of reintroducing p16INK4a using the HIV TAT delivery system to induce cancer cell death.
  • A synthetic TATp16INK4a peptide was tested on mesothelioma cells, both in lab settings and in living organisms, showing significant inhibition of Cdk4, cell cycle arrest, and ultimately cell death.
  • The study concludes that using TATp16INK4a, or similar small molecule strategies, may provide a promising treatment approach for mesothelioma by effectively inducing apoptosis and altering cell cycle progression.
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Background: The current paradigm of metastasis proposes that rare cells within primary tumors acquire metastatic capability via sequential mutations, suggesting that metastases are genetically dissimilar from their primary tumors. We tested this hypothesis by examining the molecular differences, if any, between primary tumor cells and matched lymph node metastatic cells in human non-small-cell lung carcinoma specimens.

Methods: We performed transcriptional profiling studies on malignant cells from 11 pairs of stage III tumors and their tumor-positive lymph nodes using multiple, complementary analytic techniques.

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