A concise and convergent (formal) total synthesis of huperzine A.

The first convergent synthesis of the tricyclic skeleton of huperzine A is described and includes, as the key step, an efficient regioselective intramolecular Heck reaction of 2-(tert-butyldimethylsilyloxymethyl)-6-(2-methoxy-5-bromopyridin-6-yl)methylcyclohex-2-enol.

A convergent approach to huperzine A and analogues.

We describe a concise and convergent synthesis of (rac)-5-methoxy-6-azatricyclco[7.3.1.