Reservoirs of faecal indicator bacteria in well-head hand pumps in Bangladesh.

The majority of the population of Bangladesh (90%) rely on untreated groundwater for drinking and domestic use. At the point of collection, 40% of these supplies are contaminated with faecal indicator bacteria (FIB). Recent studies have disproved the theory that latrines discharging to shallow aquifers are the major contributor to this contamination.

Microbial oxidation of arsenite in a subarctic environment: diversity of arsenite oxidase genes and identification of a psychrotolerant arsenite oxidiser.

Background: Arsenic is toxic to most living cells. The two soluble inorganic forms of arsenic are arsenite (+3) and arsenate (+5), with arsenite the more toxic. Prokaryotic metabolism of arsenic has been reported in both thermal and moderate environments and has been shown to be involved in the redox cycling of arsenic.

Two types of action error: electrophysiological evidence for separable inhibitory and sustained attention neural mechanisms producing error on go/no-go tasks.

Disentangling the component processes that contribute to human executive control is a key challenge for cognitive neuroscience. Here, we employ event-related potentials to provide electrophysiological evidence that action errors during a go/no-go task can result either from sustained attention failures or from failures of response inhibition, and that these two processes are temporally and physiologically dissociable, although the behavioral error--a nonintended response--is the same. Thirteen right-handed participants performed a version of a go/no-go task in which stimuli were presented in a fixed and predictable order, thus encouraging attentional drift, and a second version in which an identical set of stimuli was presented in a random order, thus placing greater emphasis on response inhibition.

Comparison of baroreflex sensitivity measures for assessing subjects with obstructive sleep apnea.

Baroreflex sensitivity (BRS) is assessed in subjects with and without obstructive sleep apnea (OSA) using the time domain direct sequence technique, the spectral transfer function (TF) technique and the alpha index technique. All three measures showed a significantly depressed BRS value in subjects with severe apnea. The high frequency (HF) component of the spectral measures showed higher correlation with the sequence technique measures than the low frequency (LF) component.

Predictors of decreased spontaneous baroreflex sensitivity in obstructive sleep apnea syndrome.

Background: The impact of obstructive sleep apnea syndrome (OSAS) on the arterial baroreflex, and its significance, is still under debate. We investigated the baroreflex sensitivity (BRS) during sleep in well-selected OSAS patient and control subject cohorts

Methods: We performed a prospective study of 10 non-OSAS subjects, 14 subjects with mild-to-moderate OSAS, and 14 male subjects with severe OSAS subjects. Groups were matched for age, body mass index, and other relevant variables.

Detection, diversity and expression of aerobic bacterial arsenite oxidase genes.

The arsenic (As) drinking water crisis in south and south-east Asia has stimulated intense study of the microbial processes controlling the redox cycling of As in soil-water systems. Microbial oxidation of arsenite is a critical link in the global As cycle, and phylogenetically diverse arsenite-oxidizing microorganisms have been isolated from various aquatic and soil environments. However, despite progress characterizing the metabolism of As in various pure cultures, no functional gene approaches have been developed to determine the importance and distribution of arsenite-oxidizing genes in soil-water-sediment systems.

The NT-26 cytochrome c552 and its role in arsenite oxidation.

Arsenite oxidation by the facultative chemolithoautotroph NT-26 involves a periplasmic arsenite oxidase. This enzyme is the first component of an electron transport chain which leads to reduction of oxygen to water and the generation of ATP. Involved in this pathway is a periplasmic c-type cytochrome that can act as an electron acceptor to the arsenite oxidase.

Shared services. Outsourcing. Share option.

Last April the DoH launched NHS Shared Business Services, a joint venture between the DoH and private firm Xansa. SBS guarantees an initial cost saving of 20 per cent, and organisations have found it improves procurement and management. Some organisations have had difficulties with SBS, finding the migration complex and time-consuming.

Foundations. Private problems.

PFI payments could become a huge burden to foundation trusts if they are unable to maintain income levels. Monitor has deferred some foundation applications due to concerns over unrealistic PFI figures. There have been calls for guidance on the tariff system to help trusts.

Finance. Money changes everything.

The DoH wants to introduce payment by results to mental healthcare by 2008-09. The NHS Information Authority case-mix service is developing healthcare resource groups for inpatients and community care. One way to introduce payment by results to the sector would be to pay per item of service, such as per inpatient day.

The evolution of parasites from their hosts: intra- and interspecific parasitism and Emery's rule.

In some taxa of Hymenoptera, fungi, red algae and mistletoe, parasites and their hosts are either sibling species or at least closely related (Emery's rule). Three evolutionary mechanisms have been proposed for this phenomenon: (i) intraspecific parasitism is followed by sympatric speciation; (ii) allopatric speciation is followed by secondary sympatry and the subsequent parasitism of one sibling species by the other; and (iii) allopatric speciation of a species with intraspecific parasitism is followed by secondary sympatry, in which one species becomes an obligate parasite of the other. Mechanisms (i) and (ii) are problematic, while mechanism (iii) has not, to our knowledge, been analysed quantitatively.

NHS Direct is launch pad for responsibility and status.

NHS Direct will be the launch pad that will lead A&E nurses to be given more responsibilities and stature in the NHS, according to junior health minister Lord Philip Hunt.