Mitomycin-C concentration in human aqueous humour following trabeculectomy.

The aim of the study was to determine mitomycin-C (MMC) concentrations in human aqueous humour during trabeculectomy and to correlate anterior chamber concentrations with method of application. MMC was applied intra-operatively by saturating sponges, ranging in size from 2 x 2 x 5 mm to 2 x 4 x 10 mm on dry cut, with 0.5 mg/ml MMC during trabeculectomy for 3-5 minutes.

Anti-toxoplasma serotitres in uveitis and ocular toxoplasmosis.

This study was based on anti-toxoplasma serotitres obtained from 80 normal healthy adults and 103 consecutive patients with anterior, posterior and panuveitis over a 42 month period. Twelve out of 80 (15%) normal healthy sera were found to have low titres (1:64 to 1:256), while 3 (3.8%) had high titres (1:1024 or higher).

GnRH-induced gonadotrophin secretion in ovariectomized Booroola ewes with hypothalamic-pituitary disconnection.

To test whether the F gene-specific differences in the plasma concentrations of FSH and LH are due to differences in the pituitary responsiveness to exogenous GnRH, ovariectomized Booroola ewes with hypothalamic-pituitary disconnection (HPD-ovx) were treated with GnRH (250 ng i.v.) once every 2 h for up to 5 weeks.

Anti-toxoplasma serotitres in ocular toxoplasmosis.

Serological studies are one of the important diagnostic tools used in the investigation of uveitis. This study was based on anti-toxoplasma serotitres obtained from 80 normal healthy adults and 122 patients investigated for ocular toxoplasmosis over a 42 month period. Fifteen per cent of normal healthy sera were found to have low titres (1:64 to 1:256), while 3.

Experimental Trypanosoma cruzi infection in rhesus monkeys 111. Electrocardiographic and histopathological findings.

In five rhesus monkeys surviving 'Peru strain' or 'strain 7' Trypanosoma cruzi infection for six to eight years, positive xenodiagnosis results and high indirect fluorescent antibody titres (4096 - 65536) persisted until the animals were killed. Abnormal electrocardiograph patterns in two monkeys (H and K) were possibly compatible with myocardial damage. Histopathological changes attributable to T.

Mebendazole in the treatment of helminthiasis.

Mebendazole, a new broad-spectrum anthelmintic, was used to treat patients with nematode infections--ascariasis, trichuriasis and hookworm. The dosage for adults was 100 mg twice daily for 3 days and for children, 50 mg twice daily for 3 days. Pretreatment and post-treatment egg counts on stool specimens showed that after mebendazole there was a reduction of over 99% in egg count per gram of stool in all three types of infection.

Diagnostic procedures in parasitic diseases.

This article offers some guidelines for investigating patients with suspected tropical and parasitic diseases. The common symptoms of tropical diseases as seen in Canadians returning from the tropics are discussed and diagnostic approaches suggested. Simple office laboratory procedures for the diagnosis of the common intestinal and blood parasites are outlined.

Experimental Trypanosoma cruzi infections in rhesus monkeys. II. The early chronic phase.

Information on the acute and early chronic phases of infection with Trypanosoma cruzi in eight rhesus monkeys is reported with particular reference to the pattern of subpatent parasitaemia and serology. Xenodiagnosis was superior to animal inoculation and blood culture in its capacity to detect subpatent parasitaemia. Each monkey showed an individual, relatively constant pattern of this not related to the nature of the inoculum.

The use of irradiated vaccine in immunization against experimental murine toxoplasmosis.

Trophozoites from the peritoneal cavities of mice infected with the RH strain Toxoplasma gondii were given irradiation in doses of 5, 10, 15, and 20 kiloroentgens (kr). CD-1 strain mice that received intraperitoneal inoculation of trophozoites irradiated with 5 kr all died of toxoplasmosis, but the mice that received trophozoites irradiated with the higher doses all survived. The survirors that were examined were found to be free of toxoplasmic cysts.

Chemotherapy in experimental toxoplasmosis: comparison of the efficacy of trimethoprim-sulfur and pyrimethamine-sulfur combinations.

Mice infected by intraperitoneal inoculation of the RH strain of Toxoplasma gondii were treated with various drugs. Trimethoprim was found to have no effect. Sulphamethoxazole, sulphadiazine and pyrimethamine had significant therapeutic effects on the course of murine toxoplasmosis.

Dogs and intestinal parasites: a public health problem.

The stools of 239 stray dogs were examined for intestinal parasites. Of the helminths found, Toxocara canis (43.5%), tapeworms (25.

Onchocerciasis in Canada.

The first two cases of onchocerciasis seen in Canada are reported. The patients had come from West Africa to study in Canada several months prior to admission to hospital. The presenting symptom in each case was intense pruritus.