Publications by authors named "Sea-Jin Oh"
Proc Natl Acad Sci U S A
February 2013
Article Synopsis
- Stabilizing the structure of viral proteins and nucleic acids is crucial for the effectiveness of live recombinant viral vaccines, especially when not stored in cold conditions, which is particularly important for addressing diseases like HIV globally.
- The study introduces a dissolvable microneedle array (MA) delivery system that maintains the effectiveness of live recombinant human adenovirus type 5 (rAdHu5) vaccines, resulting in strong CD8(+) T-cell responses comparable to traditional injection methods.
- Intravital imaging shows the MA cargo successfully targets dendritic cells in the skin layers, and the immunization process involves specific dendritic cell types, offering new insights into how these vaccines prime CD8(+)
