Mitochondrial Transplantation Ameliorates Pulmonary Fibrosis by Suppressing Myofibroblast Activation.

Idiopathic pulmonary fibrosis (IPF) is a pulmonary disease characterized by excessive extracellular matrix protein deposition in the lung interstitium, subsequently causing respiratory failure. IPF still has a high medical unmet requirement due to the lack of effective treatments to inhibit disease progression. The etiology of IPF remains unclear, but mitochondrial dysfunction is considered to be associated with IPF development.

Repeated intratracheal instillation effects of commonly used vehicles in toxicity studies with mice.

Intratracheal instillation (ITI) is considered the most pragmatic approach for investigating the potential toxicities of various respiratory exposure materials. Various respiratory exposure materials, including nanomaterials, hazardous air pollutants, fine dust, and household biocides, have raised public health concerns because of limited toxicological information and increasing consumption. Hence, toxicity studies using ITI in laboratory animals are important to accurately assess the human risks associated with these respiratory-exposed materials.

Association Between Self-Construals, Social Pain Sensitivity, and Gender in Young Adults.

We experience pain in response to negative, unwanted social interaction with others (e.g., social rejection), and this type of pain is termed as social pain in the recent literature.

Food insecurity and academic function among college students during the COVID-19 pandemic: A moderating role of the first-generation college student status.

Objective: To examine food insecurity (FI) prevalence among college students during the COVID-19 pandemic (April 2021) using cross-sectional design, and the moderating role of the first-generation student status in the relationship between FI and grade point average (GPA).

Participants: Three-hundred sixty students recruited mostly from upper-level kinesiology courses.

Methods: General linear model was used to predict GPA based on food security status, psychological health, and bodily pain, with subgroup analysis performed by first-generation student status.

Developmental change in predictive motor abilities.

Prediction is critical for successful interactions with a dynamic environment. To test the development of predictive processes over the life span, we designed a suite of interceptive tasks implemented as interactive video games. Four tasks involving interactions with a flying ball with titrated challenge quantified spatiotemporal aspects of prediction.

Efficient brazzein production in yeast (Kluyveromyces lactis) using a chemically defined medium.

The sweet-tasting protein brazzein offers considerable potential as a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic properties. Here, we optimized a chemically defined medium to produce secretory recombinant brazzein in Kluyveromyces lactis, with applications in mass production. Compositions of defined media were investigated for two phases of fermentation: the first phase for cell growth, and the second for maximum brazzein secretory production.

Quantitative Assessment of Learning and Retention in Virtual Vocal Function Exercises.

Purpose Successful voice therapy requires the patient to learn new vocal behaviors, but little is currently known regarding how vocal motor skills are improved and retained. To quantitatively characterize the motor learning process in a clinically meaningful context, a virtual task was developed based on the Vocal Function Exercises. In the virtual task, subjects control a computational model of a ball floating on a column of airflow via modifications to mean airflow (L/s) and intensity (dB-C) to keep the ball within a target range representing a normative ratio (dB × s/L).

Gender Differences in Throwing Revisited: Sensorimotor Coordination in a Virtual Ball Aiming Task.

Numerous studies have demonstrated that boys throw balls faster, farther and more accurately than girls. This may be largely due to well-known anatomical and muscle-physiological differences that play a central role in overarm throwing. With the objective to understand the potential contribution of the equally essential coordinative aspects in throwing for this gender difference, this large cross-sectional study examined a simplified forearm throw that eliminated the requirements that give males an advantage.

Optimized production and quantification of the tryptophan-deficient sweet-tasting protein brazzein in .

The sweet-tasting protein brazzein is a candidate sugar substitute owing to its sweet, sugar-like taste and good stability. To commercialize brazzein as a sweetener, optimization of fermentation and purification procedure is necessary. Here, we report the expression conditions of brazzein in the yeast and purification method for maximum yield.

Exploiting the geometry of the solution space to reduce sensitivity to neuromotor noise.

Throwing is a uniquely human skill that requires a high degree of coordination to successfully hit a target. Timing of ball release appears crucial as previous studies report required timing accuracies as short as 1-2ms, which however appear physiologically challenging. This study mathematically and experimentally demonstrates that humans can overcome these seemingly stringent timing requirements by shaping their hand trajectories to create extended timing windows, where ball releases achieve target hits despite temporal imprecision.

Measuring vocal motor skill with a virtual voice-controlled slingshot.

Successful voice training (e.g., singing lessons) and vocal rehabilitation (e.

Moving slowly is hard for humans: limitations of dynamic primitives.

Mounting evidence suggests that human motor control uses dynamic primitives, attractors of dynamic neuromechanical systems that require minimal central supervision. However, advantages for control may be offset by compromised versatility. Extending recent results showing that humans could not sustain discrete movements as duration decreased, this study tested whether smoothly rhythmic movements could be maintained as duration increased.

Children With Dystonia Can Learn a Novel Motor Skill: Strategies That are Tolerant to High Variability.

Children with dystonia are characterized by highly variable and seemingly uncontrolled movements. An important question for any rehabilitative effort is whether these children can learn and improve their performance. This study compared children with dystonia due to cerebral palsy, typically developing children, and healthy adults in their ability to acquire a novel sensorimotor skill.

Biofunctionalized titanium with anti-fouling resistance by grafting thermo-responsive polymer brushes for the prevention of peri-implantitis.

In the last decade, titanium has been effectively used in the dental field for oral surgery as an implant material. However, disinfected Ti can be easily re-infected by the surrounding environment. Thus, a novel anti-fouling treatment for Ti implants is currently necessary.

Comparison between organic sensitizers containing stilbene and azo group as bridging unit for dye sensitized solar cells.

While azo dyes have been widely used in dye industry, the azo dyes have been seldom applied as sensitizers to dye sensitized solar cells. In this study, new metal-free organic sensitizers, ST and AZ, which are same structures except bridging units, were synthesized and evaluated. ST containing stilbene as bridging unit gave higher energy conversion efficiency than AZ containing azo group as bridging unit.

Chitosan/polyurethane blended fiber sheets containing silver sulfadiazine for use as an antimicrobial wound dressing.

Electrospun chitosan (CTS) nanofibers have been well known for use as a wound dressing in the biomedical field. Nevertheless, fatal bacterial infections are still a serious problem when CTS nanofibers are used for wound treatment. In this study, we designed a novel wound dressing based on blending the chitosan with polyurethane (CTS/PU) containing silver sulfadiazine (AgSD) in order to enhance both antibacterial activity and mechanical strength.

Robust retention of individual sensorimotor skill after self-guided practice.

Long-term retention of a motor skill has received relatively little systematic study, even though lasting neuroplasticity is the holy grail of any clinical intervention. This study examined the acquisition and retention of a novel bimanual polyrhythmic skill, practiced with sparse explicit feedback mimicking real-life scenarios. Self-paced and metronome-paced practice conditions were compared in their effect on long-term retention.

Generation of functionalized polymer nanolayer on implant surface via initiated chemical vapor deposition (iCVD).

Initiated chemical vapor deposition (iCVD) was utilized to generate a 200nm thick, uniform, functionalized polymer nanolayer comprised of glycidyl methacrylate (GMA) on the surface of titanium implants as a means to improve cellular attachment. Dot-patterned GMA-coated specimens were prepared as well as fully coated specimens. In vitro cellular responses, including cell morphology, protein adsorption, cell proliferation assays, alkaline phosphate activity (ALP) assays, and calcium deposition assays were studied using adipose derived stem cells.

Electrospun chitosan nanofibers with controlled levels of silver nanoparticles. Preparation, characterization and antibacterial activity.

The ideal wound dressing would have properties that allow for absorption of exudates, and inhibition of microorganism for wound protection. In this study, we utilized an electrospinning (ELSP) technique to design a novel wound dressing. Chitosan (CTS) nanofibers containing various ratios of silver nanoparticles (AgNPs) were obtained.

Learning to never forget-time scales and specificity of long-term memory of a motor skill.

Despite anecdotal reports that humans retain acquired motor skills for many years, if not a lifetime, long-term memory of motor skills has received little attention. While numerous neuroimaging studies showed practice-induced cortical plasticity, the behavioral correlates, what is retained and also what is forgotten, are little understood. This longitudinal case study on four subjects presents detailed kinematic analyses of humans practicing a bimanual polyrhythmic task over 2 months with retention tests after 6 months and, for two subjects, after 8 years.

Rapid dye adsorption via surface modification of TiO2 photoanodes for dye-sensitized solar cells.

A facile method for increasing the reaction rate of dye adsorption, which is the most time-consuming step in the production of dye-sensitized solar cells (DSSCs), was developed. Treatment of a TiO2 photoanode with aqueous nitric acid solution (pH 1) remarkably reduced the reaction time required to anchor a carboxylate anion of the dye onto the TiO2 nanoparticle surface. After optimization of the reaction conditions, the dye adsorption process became 18 times faster than that of the conventional adsorption method.

Influence of solvent and bridge structure in alkylthio-substituted triphenylamine dyes on the photovoltaic properties of dye-sensitized solar cells.

Three new triphenylamine dyes that contain alkylthio-substituted thiophenes with a low bandgap as a π-conjugated bridge unit were designed and synthesized for organic dye-sensitized solar cells (DSSCs). The effects of the structural differences in terms of the position, number, and shape of the alkylthio substituents in the thiophene bridge on the photophysical properties of the dye and the photovoltaic performance of the DSSC were investigated. The introduction of an alkylthio substituent at the 3-position of thiophene led to a decrease in the degree of redshift and the value of the molar extinction coefficient of the charge-transfer band, and the substituent with a bridged structure led to a larger redshift than that of the open-chain structure.

Effect of five-membered heteroaromatic linkers to the performance of phenothiazine-based dye-sensitized solar cells.

Phenothiazine derivatives with various conjugated linkers (furan, thiophene, and 3,4-ethylenedioxythiophene) were synthesized and used in dye-sensitized solar cells to study the effect of conjugated linkers on device performance. Among them, one with furan as a conjugated linker showed a solar energy-to-electricity conversion efficiency (η) of 6.58%, an improvement of over 24% compared with the T2-1 reference cells' 5.