Publications by authors named "Se Won Ki"
Article Synopsis
- GEX1A is a microbial product that demonstrates antitumor properties by altering the processing of p27, leading to its accumulation in cancer cells.
- It inhibits pre-mRNA splicing of p27, resulting in the production of a truncated form, p27*, which accumulates due to its resistance to proteolysis.
- GEX1A targets the SAP155 protein, a part of the pre-mRNA splicing machinery, establishing it as a unique splicing inhibitor that disrupts SF3b function.
