Publications by authors named "Se J Park"
Objective: Claudin18.2 has been established as a putative therapeutic target in human solid malignancies. The aim of this study is to determine claudin18.
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- PTSD is a serious mental health condition triggered by traumatic events, with symptoms like anxiety, depression, and negative mood changes.
- Traditional treatments have limited effectiveness and side effects, prompting research into 4-methoxycinnamic acid (4-MCA) as a new potential therapy for PTSD.
- Studies on mice showed that 4-MCA significantly reduced anxiety and depression, improved cognitive function, and corrected fear-related issues, suggesting it may work by impacting specific brain signaling pathways related to fear memory.
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- * This study introduced a new method using a respirometer to measure oxygen consumption in ICR mice exposed to various concentrations of benzene, toluene, and xylene, revealing significant decreases in respiration rates at high concentrations of benzene and toluene.
- * The method was validated in a model of pulmonary fibrosis, showing a strong link between weight loss and decreased oxygen consumption, suggesting oxygen consumption might serve as a reliable endpoint in inhalation toxicity assessments without needing to sacrifice animals.
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- The study focuses on the benefits of barley husk, specifically its water-soluble xylan (BH-WSX), highlighting its high dietary fiber and prebiotic content that support gut health.
- Researchers extracted BH-WSX and found it to have a significant yield, specific molecular characteristics, and antioxidant properties, suggesting it could be useful for food applications.
- Advanced analyses, including spectroscopy and thermal testing, confirmed the chemical composition and structure of BH-WSX, making it a promising candidate for enhancing gut microbiota and potentially preventing adhesion of harmful bacteria.
Adenocarcinoma of the ampulla of Vater (AAC) is a rare malignancy with heterogeneous tumors arising from various histologic subtypes, necessitating new therapeutic strategies. This study examines epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and c-Met expression in AAC, given their potential as druggable targets. Among 87 patients who underwent curative resection, EGFR overexpression was found in 87.
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- The skin serves as a protective barrier against external irritants, and Pilea mongolica (P. mongolica) is a traditional Chinese herb that may help reduce inflammation, despite limited research on its effects.
- This study investigated the anti-inflammatory properties of the methanol extract of P. mongolica (MEPM) on LPS-stimulated human skin cells, showing that it significantly lowered inflammatory markers without being toxic to the cells.
- The study identified geraniin, an active compound in MEPM, as a key player in these anti-inflammatory effects, suggesting that MEPM and geraniin could be valuable for developing natural cosmetic products.
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- Adenocarcinoma of the ampulla of Vater (AoV) is a rare type of cancer that presents challenges in treatment, and this study examines the effectiveness of capecitabine and oxaliplatin (CAPOX) in real-world settings.
- The study involved 42 patients with advanced AoV carcinoma, assessing their treatment experiences, progression-free survival (4.38 months), and overall survival (9.57 months), with notable differences in outcomes depending on whether CAPOX was received as a first or second-line treatment.
- CAPOX therapy had a manageable safety profile; however, neutropenia was the most common severe side effect, and some patients experienced treatment discontinuation due to fatigue and peripheral neuropathy.
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- Cheonwangbosimdan (CWBSD) is a traditional herbal medicine known for treating anxiety, insomnia, depression, and heart palpitations, and shows potential in reducing PTSD-like behaviors.
- The study employed a mouse model of PTSD to test CWBSD’s effects on various behavioral tests, signaling improvements in anxiety, depression, and cognitive function.
- Results indicated that CWBSD improved emotional and cognitive issues in PTSD-like mice and potentially normalized certain protein levels in the amygdala affected by stress.
Pancreatic ductal adenocarcinoma (PDAC) is notorious for its aggressive progression and dismal survival rates, with this study highlighting elevated interleukin 6 (IL-6) levels in patients as a key marker of increased disease severity and a potential prognostic indicator. Analyzing pre-treatment serum from 77 advanced PDAC patients via ELISA, the research determined optimal cutoff values for IL-6 and the IL-6:sIL-6Rα ratio using receiver operating characteristic curve analysis, which then facilitated the division of patients into low and high IL-6 groups, showing significantly different survival outcomes. Notably, high IL-6 levels correlated with adverse features such as poorly differentiated histology, higher tumor burden, and low albumin levels, indicating a stronger likelihood of poorer prognosis.
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- Particulate matter (PM) pollution, linked to various health issues, has not been thoroughly studied in relation to the development of schizophrenia.
- This study exposed preadolescent mice to PM and examined the impact on schizophrenia-like behaviors, finding that PM exposure worsened symptoms like social deficits and cognitive impairments in adulthood.
- The research also revealed that PM exposure reduced levels of brain-derived neurotrophic factor (BDNF) and affected related signaling pathways, suggesting a biological mechanism behind the exacerbation of schizophrenia symptoms.
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- The study focused on understanding the genotype-phenotype relationships in children with Gitelman syndrome (GS) by analyzing genetic variations in the SLC12A3 gene in 50 Korean children.
- The median age for diagnosis was 10.5 years, with 68% having biallelic variants; those with truncating variants experienced more severe electrolyte imbalances compared to those without.
- Findings suggest that children with monoallelic SLC12A3 variants exhibited similar clinical symptoms and treatment responses as those with biallelic variants.
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- PTSD is a mental illness that arises from trauma, and current treatments are often ineffective and have significant side effects.
- This study explored the potential of D-Pinitol, shown to help depression and anxiety, in a mouse model of PTSD, finding it improved symptoms and cognitive functions.
- D-Pinitol works by antagonizing the mineralocorticoid receptor, which may help explain its effectiveness in reducing PTSD-like behaviors and fear responses in the tested mice.
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- * A study tested the effects of a novel herbal complex called LK5, which has anti-inflammatory properties, on HaCaT cells and in a mouse model of AD.
- * Results showed that LK5 reduced expression of inflammatory cytokines, improved clinical symptoms in mice, and inhibited itch, indicating its potential to modulate the immune response and alleviate AD symptoms by targeting the JAK-STAT pathway.
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- This study focuses on improving lung cancer diagnosis through a new test that analyzes DNA methylation from bronchial washing cytology, which has shown better sensitivity compared to traditional bronchoscopy methods.
- Researchers enrolled 187 patients with suspicious CT lesions and performed tests on two specific methylation biomarkers, revealing that the combination of both tests increased diagnostic sensitivity.
- The findings suggest that using DNA methylation analysis could potentially reduce the need for invasive procedures like biopsies in detecting lung cancer.
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- This study focused on childhood-onset lupus nephritis (LN), examining the clinical features, kidney outcomes, and risk factors related to prognosis in 216 patients across South Korea.
- Most patients presented with nephrotic syndrome or hematuria, and the most common kidney damage was WHO class IV LN, with nearly 15% developing advanced chronic kidney disease (CKD) after an average follow-up of about 8 years.
- Key risk factors identified for advanced CKD included being male and not achieving remission within the first year of treatment, indicating the need for careful monitoring of these patients to improve their long-term outcomes.
Background: We conducted a trial to evaluate the efficacy and safety of nivolumab and paclitaxel as second-line therapy for immune-related biomarker-enriched advanced gastric cancer (AGC).
Methods: This open-label, single-arm, phase Ib/II study was a part of multi-institutional, biomarker-integrated umbrella study conducted in Korea. In phase Ib, patients received nivolumab (3 mg/kg) on Days 1 and 15 and paclitaxel (dose level 1, 70 mg/m or dose level 2, 80 mg/m) on Days 1, 8, 15 every four weeks.
Patients with ampulla of Vater adenocarcinoma exhibit diverse outcomes, likely since these malignancies can originate from any of the three converging epithelia at this site. Such variability presents difficulties in clinical decision-making processes and in devising therapeutic approaches. In this study, the potential clinical value of histomolecular phenotypes was determined by integrating histopathological analysis with protein expression (MUC1, CDX2, CK20, and MUC2), in a cohort of 87 patients diagnosed with stage IB to III ampulla of Vater adenocarcinoma who underwent curative surgical resection.
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- Electroencephalography (EEG) is a method used to study human behavior by monitoring brain activity during various tasks, while machine learning (ML) helps recognize these activities.
- This study aimed to see how well an EEG-based ML model could categorize daily activities like resting, walking, and reading, and to use explainable AI techniques to understand which EEG features were most important in these classifications.
- The research involved 75 healthy participants and found that ML models like Random Forest and Gradient Boosting performed excellently in differentiating activities, with clear correlations found between machine learning results and EEG spectral data, suggesting potential benefits for healthcare and rehabilitation applications.
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- - The study aimed to investigate the connection between changes in the pericruciate fat pad (PCFP) seen on MRI and the severity of cartilage damage in the knee.
- - Involving 234 patients, two radiologists graded the PCFP signal changes and cartilage lesions, finding significant correlations between the grades of PCFP change and cartilage alterations, particularly in the medial knee compartment.
- - The results suggest that PCFP signal changes could serve as an indicator of osteoarthritis in patients, related to other knee issues like bone marrow lesions and meniscal tears.
The clinical significance of PD-1 expression in circulating CD8 T cells in patients with gastric cancer (GC) receiving chemotherapy remains unelucidated. Therefore, we aimed to examine its prognostic significance in blood samples of 68 patients with advanced GC who received platinum-based chemotherapy. The correlation between peripheral blood mononuclear cells, measured using fluorescence-activated cell sorting, was evaluated.
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- Interest in using fermented sprouts from smart farms is growing due to their health benefits, particularly in reducing inflammation.
- A study found that a fermented extract of CL sprouts (F-CSA) exhibited significant anti-inflammatory effects by reducing harmful cytokines in macrophage cells and mice.
- The anti-inflammatory action of F-CSA is linked to its high luteolin content and its ability to inhibit the JNK/NF-κB signaling pathway, showing potential for therapeutic applications in inflammatory conditions.
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- The NLRP3 inflammasome, which is promoted by certain agents, plays a key role in increasing IL-1β levels, contributing to the worsening of atopic dermatitis (AD) symptoms.
- Despite its critical role, there are currently no drugs specifically targeting the NLRP3 inflammasome for AD patients.
- Research showed that MAEO can inhibit NLRP3 inflammasome activation and reduce AD symptoms in laboratory tests and animal models, suggesting its potential as a treatment for AD.
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- Cynanchum paniculatum has a history of use in East Asia for its pain-relieving and antiviral properties, and traditional texts indicate potential benefits for treating psychotic symptoms like hallucinations and delusions.
- The study investigated the effects of C. paniculatum and its main compound, paeonol, on mice with schizophrenia-like behaviors induced by MK-801, finding that paeonol may help alleviate symptoms.
- Results showed that both C. paniculatum extract and paeonol improved sensorimotor gating and cognitive deficits in the mice, suggesting paeonol could be a promising treatment for schizophrenia-related issues.
Background: Interactions between the programmed cell death receptor 1 (PD-1) and its ligand (PD-L1) lead to immune evasion in various tumors and are associated with poor prognosis in patients with pancreatic cancer; however, the roles of PD-L1-containing exosomes in pancreatic cancer is poorly understood. Here, we investigated the correlation between circulating exosomal PD-L1 (exoPD-L1) and PD-L1 expression in tumor tissue, and survival outcomes in patients with advanced PDAC.
Methods: Exosomes were derived from pre-treatment serum samples isolated using ExoQuick kit from 77 patients with advanced pancreatic cancer.
Role of adjuvant chemotherapy on recurrence and survival in patients with resected ampulla of Vater carcinoma.
World J Gastrointest Oncol
April 2023
Background: Owing to rarity of disease and lack of prospective studies, data supporting the role of adjuvant chemotherapy in ampulla of Vater (AoV) carcinoma is limited.
Aim: To evaluate whether adjuvant chemotherapy cases for AoV carcinoma had better disease-free survival (DFS) rates than cases of observation following curative surgery.
Methods: We retrospectively analyzed the association between adjuvant chemotherapy and DFS and overall survival (OS) in patients with stage IBIII AoV carcinoma who underwent curative surgical resection.