Publications by authors named "Scott W Allen"

Scarf et al. (Proc Natl Acad Sci 113(40):11272-11276, 2016) demonstrated that pigeons, as with baboons (Grainger et al. in Science 336(6078):245-248, 2012; Ziegler in Psychol Sci.

View Article and Find Full Text PDF
Article Synopsis
  • - The study focuses on preparing for the clinical development of Ab-01, an antibody targeting IL21R, by addressing key needs like developing a biomarker assay and demonstrating the antibody's efficacy in both human and cynomolgus monkey models.
  • - Researchers identified gene expression changes in blood samples from humans and monkeys after stimulation with rhIL21, which were successfully blocked by Ab-01, indicating its biological activity and relevance for safety studies.
  • - The findings confirm that the developed pharmacodynamic biomarker assay is effective for clinical application, allowing the measurement of Ab-01's activity in treated subjects.
View Article and Find Full Text PDF
Article Synopsis
  • * They found that rifampicin significantly induced CYP3A4, and the best results were achieved at a concentration of 10 microM, while omeprazole was identified as the most potent inducer at 200 microM.
  • * The study highlighted that the presence of the pregnane X receptor (PXR) enhances the ability to rank CYP3A4 induction, and the developed system allows for efficient screening of various chemicals for their potential to induce this enzyme.
View Article and Find Full Text PDF

Although CYP2C8, CYP2C9, and CYP2C19 play an important role in drug biotransformation, factors influencing the expression and activity of these CYP2C P450s in human liver remain largely undefined. We used primary cultures of human hepatocytes from 15 subjects to assess the inducibility of CYP2C enzyme expression by prototypical inducer agents, including rifampicin, dexamethasone, and phenobarbital. After culture for 72 h in serum-free medium on collagen, Western blotting revealed that CYP2C9 was the only CYP2C enzyme expressed at appreciable levels in untreated hepatocytes.

View Article and Find Full Text PDF

We report a failure to find a repetition deficit in recall following the rapid serial visual presentation (RSVP) of words within sentences, using adjectives rather than nouns as the critical items. In a series of experiments that ruled out participant and procedural differences as the source of the failure, both word class and list context were found to moderate the repetition deficit, but grammatical necessity did not. The presence in the list of sentences in which the repeated adjectives were separated by more than three words (i.

View Article and Find Full Text PDF