Publications by authors named "Scott Stayner"
Introduction Evoked compound action potentials (ECAPs) during spinal cord stimulation (SCS) may be useful in the treatment of chronic pain as a control signal for closed-loop neuromodulation. However, considerable inter-individual variability in evoked responses requires robust methods in order to realize effective, personalized pain management. These methods include artifact removal, feature extraction, classification, and prediction.
View Article and Find Full Text PDFPerioperative Management of Antiplatelet and Anticoagulant Therapy in Patients Undergoing Interventional Techniques: 2024 Updated Guidelines from the American Society of Interventional Pain Physicians (ASIPP).
Pain Physician
August 2024
Article Synopsis
- The increasing use of interventional techniques in chronic pain patients on anticoagulant and antiplatelet therapy poses challenges in balancing the bleeding risk from these medications and the thrombosis risk from discontinuation.
- Guidelines have been developed through a literature review and expert consensus to help assess and manage the risks of bleeding and thrombosis during interventional procedures for these patients.
- These guidelines provide a framework for healthcare professionals to make informed decisions regarding the continuation or temporary suspension of anticoagulant and antiplatelet therapy in the context of interventional pain management.
Background: Cervical epidural steroid injections have long been utilized to treat intraspinal inflammation causing cervicalgia and/or cervical radiculopathy, and much has been written about safety and efficacy. There are published opinions, without evidence basis, that these injections should not be performed above C7-T1 for fear of dural puncture, spinal cord injury, and other complications that might occur more frequently at higher spinal levels. However, many experienced interventional pain physicians believe that epidural injections targeted to the level of spinal inflammation may be more effective.
View Article and Find Full Text PDFArticle Synopsis
- About 100 million Americans live with chronic pain, and while opioids are commonly prescribed for treatment, their misuse is a growing nationwide issue.
- Laws and standards governing opioid prescribing are frequently updated, with initiatives like the National Drug Control Policy and various state prescription monitoring programs in place to manage prescription drug abuse.
- Balancing the need for effective pain treatment with the prevention of prescription drug abuse is crucial, and healthcare providers must stay informed about evolving regulations to ensure patient safety and care.
The genetic addition of hexahistidine (H(6)) tags is widely used to isolate recombinant proteins by immobilized metal-affinity chromatography (IMAC). Addition of a tyrosine residue to H(6) tags enabled proteins to be covalently cross-linked under mild conditions in a manner similar to the natural, site-specific cross-linking of tyrosines into dityrosine. A series of seven hexahistidine tags with tyrosines placed in various positions (H(6)Y tags) were added to the amino terminus of the I28 immunoglobulin domain of the human cardiac titin.
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