A Review on the Effects of Aerobic Exercise on Immune Dysregulation in Polycystic Ovarian Syndrome.

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of reproductive-aged females. However, much of its pathophysiology is not well investigated or understood. Research has demonstrated an association between PCOS and metabolic dysfunction, including insulin resistance.

The Drosophila ramshackle gene encodes a chromatin-associated protein required for cell morphology in the developing eye.

We have identified ramshackle (ram) as a dominant suppressor of hedgehog loss-of-function in the developing Drosophila eye. We have characterized the gene and it encodes a double bromodomain protein with eight WD40 repeats. The Ram protein is localized predominantly to polytene chromosome interbands and is required for the transcription of some genes.