Effects of an external pneumatic compression device vs static compression garment on peripheral circulation and markers of sports performance and recovery.

Purpose: To identify the effects of a single 30 min partial lower leg external pneumatic compression (EPC) treatment compared to a static compression (SC) garment or a no treatment control (CTL) on markers of recovery and performance following a muscle damaging protocol.

Methods: Thirty healthy, active males (23 ± 3 years; 180.2 ± 9.

Caffeine Timing Improves Lower-Body Muscular Performance: A Randomized Trial.

Little is known about the optimal time to consume caffeine prior to exercise to maximize the ergogenic benefits of the substance. To determine the optimal pre-exercise time interval to consume caffeine to improve lower-body muscular performance. A secondary aim was to identify the presence of any sex differences in responses to timed caffeine administration.

Single-agent belantamab mafodotin for relapsed/refractory multiple myeloma: analysis of the lyophilised presentation cohort from the pivotal DREAMM-2 study.

DREAMM-2 (NCT03525678) is an ongoing global, open-label, phase 2 study of single-agent belantamab mafodotin (belamaf; GSK2857916), a B-cell maturation antigen-targeting antibody-drug conjugate, in a frozen-liquid presentation in patients with relapsed/refractory multiple myeloma (RRMM). Alongside the main study, following identical inclusion/exclusion criteria, a separate patient cohort was enrolled to receive belamaf in a lyophilised presentation (3.4 mg/kg, every 3 weeks) until disease progression/unacceptable toxicity.

Position-Specific Body Composition Values in Female Collegiate Rugby Union Athletes.

Harty, PS, Zabriskie, HA, Stecker, RA, Currier, BS, Moon, JM, Richmond, SR, Jagim, AR, and Kerksick, CM. Position-specific body composition values in female collegiate rugby union athletes. J Strength Cond Res 35(11): 3158-3163, 2021-Rugby union is a full-contact, intermittent team sport.

Physiologic, Metabolic, and Nutritional Attributes of Collegiate Synchronized Swimmers.

Synchronized swimming is a sport that requires high levels of strength, power, and endurance, as well as artistic skill to perform in an aquatic environment. The purpose of this study was to identify physiological characteristics and dietary habits of collegiate synchronized swimmers. A total of 21 female participants (mean [SD] age = 20.

Changes in Energy Expenditure, Dietary Intake, and Energy Availability Across an Entire Collegiate Women's Basketball Season.

Zanders, BR, Currier, BS, Harty, PS, Zabriskie, HA, Smith, CR, Stecker, RA, Richmond, SR, Jagim, AR, and Kerksick, CM. Changes in energy expenditure, dietary intake, and energy availability across an entire collegiate women's basketball season. J Strength Cond Res 35(3): 804-810, 2021-The purpose of this study was to identify changes in energy expenditure and dietary intake across an entire women's basketball season.

Resistance exercise and aerobic exercise when paired with dietary energy restriction both reduce the clinical components of metabolic syndrome in previously physically inactive males.

The purpose of this study was to compare resistance exercise training (RT) to aerobic exercise training (AE) on the clinical risk factors for metabolic syndrome (MetSyn) in physically inactive overweight males (age 27-48 years). Subjects with at least one risk factor for MetSyn performed RT (n = 13, age 35.1 ± 4.

HIV-protease inhibitors suppress skeletal muscle fatty acid oxidation by reducing CD36 and CPT1 fatty acid transporters.

Infection with human immunodeficiency virus (HIV) and treatment with HIV-protease inhibitor (PI)-based highly active antiretroviral therapies (HAART) is associated with dysregulated fatty acid and lipid metabolism. Enhanced lipolysis, increased circulating fatty acid levels, and hepatic and intramuscular lipid accumulation appear to contribute to insulin resistance in HIV-infected people treated with PI-based HAART. However, it is unclear whether currently prescribed HIV-PIs directly alter skeletal muscle fatty acid transport, oxidation, and storage.

Forskolin attenuates the action of insulin on the Akt-mTOR pathway in human skeletal muscle.

Forskolin (FSK) is capable of both stimulating and inhibiting the intracellular signaling pathways of protein synthesis tissues other than skeletal muscle. The purpose of this investigation was to determine if FSK administration affects various elements of the protein kinase B (Akt)-mammalian target of rapamycin (mTOR) pathway in human skeletal muscle. Ten (n = 10) healthy, young (21.

Diathermy treatment increases heat shock protein expression in female, but not male skeletal muscle.

Heat shock treatments have been used to appreciably increase heat shock protein 70 (Hsp70) content and the phosphorylation of heat shock protein 27 (Hsp27p). The purpose of this investigation was to determine whether diathermy can increase Hsp70 and Hsp27p content in skeletal muscle. Fourteen subjects (7 males and 7 females, 18-35 years) received a muscle biopsy from the v.

Age-related changes in relative expression of real-time PCR housekeeping genes in human skeletal muscle.

The purpose of this investigation was to examine the expression of three commonly used housekeeping genes -- glyceraldehyde-3-phosphate dehydrogenase (GAPDH), beta(2)-microglobulin (beta(2)M), and RNA polymerase 2a (polR2a) -- in elderly (E) compared to young (Y) subjects. Nine young subjects (22.7 +/- 3.

Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.

Objective: This study examined the effect of forskolin on body composition, testosterone, metabolic rate, and blood pressure in overweight and obese (BMI > or = 26 kg/m(2)) men.

Research Methods And Procedure: Thirty subjects (forskolin, n = 15; placebo, n = 15) were studied in a randomized, double-blind, placebo-controlled study for 12 weeks.

Results: Forskolin was shown to elicit favorable changes in body composition by significantly decreasing body fat percentage (BF%) and fat mass (FM) as determined by DXA compared with the placebo group (p < or = 0.

Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age.

The primary mechanism that contributes to decreasing skeletal muscle strength and size with healthy aging is not presently known. This study examined the contribution of the ubiquitin-proteasome pathway and apoptosis to skeletal muscle wasting in older adults (n = 21; mean age = 72.76 +/- 8.

Insulin-like growth factor I-mediated skeletal muscle hypertrophy is characterized by increased mTOR-p70S6K signaling without increased Akt phosphorylation.

Background: Insulin-like growth factor I (IGF-I) is an anabolic hormone that is known to induce skeletal muscle hypertrophy. However, the signaling pathways mediating IGF-I's hypertrophic effect in vivo are unknown.

Method: The phosphorylation of 46 proteins was investigated by Kinetworks proteomic analysis in the gastrocnemius muscle of transgenic mice overexpressing IGF-I myosin light chain/muscle specific IGF-I (MLC/mlgf-I) and wild-type littermates.

The effects of varied rest periods between sets to failure using the bench press in recreationally trained men.

The purpose of this study was to determine the rate of recovery for recreational weight trainers between 2 sets of bench press to volitional exhaustion. Twenty-eight men performed 2 sets of the bench press at 75% of their previously determined 1 repetition maximum (1RM) to volitional exhaustion. Rest periods of 1, 3, or 5 minutes between sets were utilized on the 3 separate testing days.

Postprandial metabolism in resistance-trained versus sedentary males.

Introduction: This investigation examined if postprandial metabolism differed between resistance-trained [(RT), N = 12] and sedentary [(SED), N = 12] males. A secondary objective was to determine whether different resistance-training programs [bodybuilding (BB), N = 8 and power/weight-lifting (PL), N = 8] resulted in disparate effects on postprandial energy metabolism.

Methods: Moderate fat [(MF), 37% carbohydrate, 18% protein, and 45% fat] and high carbohydrate [(HC), 79% carbohydrate, 20% protein, and 1% fat] meals were randomly administered, and postprandial metabolism was measured for 240 min.

Effects of liquid carbohydrate ingestion on markers of anabolism following high-intensity resistance exercise.

We examined the effects of liquid carbohydrate (CHO) supplementation on markers of anabolism following high-intensity resistance exercise. Nine resistance-trained men consumed either CHO or placebo (PLC) 10 minutes before and immediately following 2 resistance exercise sessions. Cortisol (CORT), insulin (INS), ammonia (AMM), and glucose (GLU) were measured before, immediately after, and 1.