Platelet rich plasma injection for acute Achilles tendon rupture: PATH-2 randomised, placebo controlled, superiority trial.

Objective: To determine whether an injection of platelet rich plasma improves outcomes after acute Achilles tendon rupture.

Design: Randomised, placebo controlled, two arm, parallel group, participant and assessor masked, superiority trial.

Setting: Secondary care trauma units across 19 hospitals in the United Kingdom's health service.

O-substituted alkyl aldehydes for rhodium-catalyzed intermolecular alkyne hydroacylation: the utility of methylthiomethyl ethers.

Combining α-methylthiomethyl (MTM) ether substituted aldehydes and 1-alkynes in the presence of [Rh(dppe)]ClO(4) results in efficient intermolecular alkyne hydroacylation to deliver α-O-MTM-substituted enone products. The product MTM ethers can be converted to the free hydroxyl group either in situ, by the addition of water to the completed reaction, or in a separate operation, by the action of silver nitrate.