sp. nov. sp. nov., sp. nov., sp. nov. and sp. nov., five novel lactic acid bacteria isolated from insects or flowers of Kangaroo Island, South Australia.

Six strains, KI11_D11, KI4_B1, KI11_C11, KI16_H9, KI4_A6 and KI3_B9, were isolated from insects and flowers on Kangaroo Island, South Australia. On the basis of 16S rRNA gene phylogeny, strains KI11_D11, KI4_B1, KI11_C11, KI16_H9, KI4_A6 were found to be closely related to Ru20-1. Due to the lack of a whole genome sequence for this species, whole genome sequencing of Ru20-1 was undertaken.

sp. nov., gen. nov. sp. nov., sp. nov. and sp. nov., four new lactic acid bacterial isolates from stingless bees and .

Four strains, SG5_A10, SGEP1_A5, SG4_D2, and SG4_A1, were isolated from the honey or homogenate of Australian stingless bee species and . Based on 16S rRNA gene phylogeny, core gene phylogenetics, whole genome analyses such as determination of amino acid identity (AAI), cAAI of conserved genes, average nucleotide identity (ANI), and digital DNA-DNA hybridization (dDDH), chemotaxonomic analyses, and the novel isolation sources and unique geography, we propose three new species and one genus with the names sp. nov.

Vesicular acetylcholine transporter defect underlies devastating congenital myasthenia syndrome.

Objective: To identify the genetic basis of a recessive congenital neurologic syndrome characterized by severe hypotonia, arthrogryposis, and respiratory failure.

Methods: Identification of the responsible gene by exome sequencing and assessment of the effect of the mutation on protein stability in transfected rat neuronal-like PC12 cells.

Results: Two brothers from a nonconsanguineous Yemeni Jewish family manifested at birth with severe hypotonia and arthrogryposis.