Publications by authors named "Scott M Law"
Article Synopsis
- The study focuses on creating peptide-based ligands using a method called protein catalyzed capture (PCC) to improve molecular binders for sensing and drug delivery.
- Two specific peptides were enhanced: one targeting vascular endothelial growth factor (VEGF) for imaging in living organisms, showing stability and a suitable half-life, and another targeting the protective antigen (PA) of Bacillus anthracis for use in challenging conditions without losing function.
- The research highlights the effectiveness of the PCC screening process in developing advanced alternatives to traditional antibodies for diagnostics and therapeutics.
Concomitant advances made by the Human Genome Project and in the development of nucleic acid screening technologies are driving the expansion of pharmacogenomic research and molecular diagnostics. However, most current technologies are restrictive due to their complexity and/or cost, limiting the potential of personalized medicine. The invader assay, which can be used for genotyping as well as for gene expression monitoring without the need for intervening target amplification steps, presents an immediate solution that is accurate, simple to use, scaleable and cost-effective.
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