Publications by authors named "Scott E Leonard"
Article Synopsis
- The XP-D/DinG family of DNA helicases, including YoaA from E. coli, plays a crucial role in maintaining genomic stability across all life forms, particularly by aiding in DNA repair and assisting in tolerance to inhibitors like AZT.
- YoaA interacts with the DNA polymerase III component HolC, and this interaction appears to inhibit HolC's normal function, as YoaA's overexpression leads to growth inhibition in E. coli.
- The expression of YoaA is regulated by the LexA protein and responds to DNA damage conditions, with its induction being influenced by the cell's growth phase and nutritional state, suggesting a complex relationship between DNA replication and repair mechanisms
