Myogenic mRNA markers in young and old human skeletal muscle prior to and following sequential exercise bouts.

This study examined how multiple bouts of conventional resistance training affected the mRNA expression of transcripts and a protein associated with satellite cell activity in human skeletal muscle. Ten younger men (means ± SE; age, 21.0 ± 0.

Effects of age on serum hormone concentrations and intramuscular proteolytic signaling before and after a single bout of resistance training.

This study examined mRNA expression patterns for atrogin-1 and muscle ring finger-1 (MuRF-1) before and 24 hours after a resistance training bout. Furthermore, basal, 5-minute and 24-hour postexercise serum concentrations of cortisol and insulin like growth factor-1 (IGF-1) and the relationships between these hormones and the genetic expression patterns of atrogin-1 and MuRF-1 were examined. Younger and older men completed a resistance exercise bout consisting of 3 × 10 repetitions at 80% of their predetermined 1 repetition maximum for Smith squat, leg press and leg extension.

Effects of a mineral antioxidant complex on clinical safety, body water, lactate response, and aerobic performance in response to exhaustive exercise.

Background: This investigation examined the safety and efficacy of a silica-based mineral antioxidant complex (MAC) that has been suggested to influence body water and buffer lactate.

Methods: In a double-blind, randomized crossover design, male participants completed testing for 3 conditions: water only (baseline), rice flour (placebo), and MAC supplementation. Participants visited the laboratory on 5 occasions: familiarization, baseline, Testing Day 1, washout, and Testing Day 2.

IGF-1 splice variant and IGF-1 peptide expression patterns in young and old human skeletal muscle prior to and following sequential exercise bouts.

Genes and proteins involved in insulin-like growth factor (IGF)-1 signaling are thought to be differentially expressed in older versus younger mammalian skeletal muscle following acute exercise. The purpose of this study was to examine how multiple bouts of conventional resistance training meant to elicit hypertrophy affect the mRNA expression of IGF-1EA and IGF-1EC (MGF) as well as the expression of total IGF-1 peptides in human skeletal muscle. Ten younger (18-25 years) and 10 older (60-75 years) males completed three sequential workouts (M, W, F) consisting of nine sets of lower body exercises with ten repetitions per set at an intensity of 80% of one repetition maximum.

Molecular attributes of human skeletal muscle at rest and after unaccustomed exercise: an age comparison.

The current study examined muscle DNA and protein concentrations ([ ]) and the [RNA] (assumed to represent translational capacity), [RNA]:[DNA] (assumed to represent transcriptional efficiency) and [protein]:[RNA] (assumed to represent translational efficiency) in younger vs. older participants during a resting state. Further, changes in muscle [DNA], translational capacity, and transcriptional efficiency were analyzed 24 hours after an unaccustomed resistance exercise bout.

Effects of preexercise feeding on markers of satellite cell activation.

Purpose: The purpose of this study was to determine if consuming isoenergetic (25 g) doses of carbohydrate or protein versus a noncaloric placebo before conventional resistance training affected the myogenic expression of cell cycle-regulating genes as well as the muscle [DNA] acutely after exercise.

Methods: Ten untrained men (mean +/- SD: age = 22 +/- 4 yr, body mass = 77.8 +/- 8.

The expression of androgen-regulated genes before and after a resistance exercise bout in younger and older men.

This cross-sectional study examined aging and resistance exercise-related changes in intramuscular gene expression in younger (21.3 +/- 0.6 years, 84.

Efficacy and safety of a popular thermogenic drink after 28 days of ingestion.

Background: We have recently demonstrated that consuming a thermogenic drink (TD) acutely increases energy expenditure and serum markers of lipolysis in healthy, college-aged individuals. The purpose of this study was to determine if consuming TD over 28 days affects its acute thermogenic and lipolytic effects as well as body composition and clinical chemistry safety markers.

Methods: Sixty healthy, males (mean +/- SE; 23 +/- 1 years, 177 +/- 2 cm, 81.