Clinical and laboratory characteristics of patients with novel coronavirus disease-2019 infection and deep venous thrombosis.

Objective: Early reports suggest that patients with novel coronavirus disease-2019 (COVID-19) infection carry a significant risk of altered coagulation with an increased risk for venous thromboembolic events. This report investigates the relationship of significant COVID-19 infection and deep venous thrombosis (DVT) as reflected in the patient clinical and laboratory characteristics.

Methods: We reviewed the demographics, clinical presentation, laboratory and radiologic evaluations, results of venous duplex imaging and mortality of COVID-19-positive patients (18-89 years) admitted to the Indiana University Academic Health Center.

Impact of Geographical Cohorting in the ICU: An Academic Tertiary Care Center Experience.

Unlabelled: ICU is a multifaceted organization where multiple teams care for critically ill patients. In the current era, collaboration between teams and efficient workflows form the backbone of value-based care. Geographical cohorting is a widespread model for hospitalist rounding, but its role in ICUs is unclear.

FEV1/FVC ratio of 70% misclassifies patients with obstruction at the extremes of age.

Background: The American Thoracic Society recommends using the lower limit of normal (LLN) method to diagnose obstructive lung disease. However, few studies have investigated the clinical relevance of these recommendations. We compared the LLN derived from available data sets to a fixed ratio (FEV1/FVC, < 75% or 70%) and also to the FEV1/FVC percent predicted ratio to determine the impact of changing the FEV1/FVC "cutoff" on the spirometric diagnosis of obstructive lung disease.

Poultry litter application to loblolly pine forests: growth and nutrient containment.

Forestland application of poultry manure offers an alternative to the conventional practice of pastureland application. Before such a practice is considered viable, however, it must be demonstrated that the forest ecosystem is capable of absorbing the nutrients contained in poultry manure, especially nitrogen (N) and phosphorus (P). From the forestry perspective, it must also be demonstrated that tree growth is not diminished.

CD4+CD28-T cells are expanded in sarcoidosis.

Background And Aim: A subset of CD4+ lymphocytes lacking CD28, an important costimulatory molecule, is increased in certain inflammatory conditions. However, studies have not directly studied CD4+CD28-lymphocytes in patients with chronic sarcoidosis. The aim of this study was to further characterize the CD4+CD28-T cell population in patients with sarcoidosis, particularly those with active disease.

Refractory sarcoidosis responding to infliximab.

Despite aggressive treatment with conventional therapy, sarcoidosis may be progressive and debilitating. Tumor necrosis factor (TNF)-alpha is critical in the genesis and maintenance of granulomatous inflammation. Agents developed to inhibit TNF-alpha have been approved to treat rheumatoid arthritis and inflammatory bowel disease with unprecedented success.